Cochlear implantation for chronic electrical stimulation in the mouse.
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Date
2013-12
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
The mouse is becoming an increasingly attractive model for auditory research due to the
number of genetic deafness models available. These genetic models offer the researcher an
array of congenital causes of hearing impairment, and are therefore of high clinical relevance.
To date, the use of mice in cochlear implant research has not been possible due to the lack of an
intracochlear electrode array and stimulator small enough for murine use, coupled with the
difficulty of the surgery in this species. Here, we present a fully-implantable intracochlear
electrode stimulator assembly designed for chronic implantation in the mouse. We describe the
surgical approach for implantation, as well as presenting the first functional data obtained from
intracochlear electrical stimulation in the mouse.
Description
Keywords
Cochlear Implant, Mouse, Chronic Electrical Stimulation, Fully Implantable, Prosthesis, Bionic, Ototoxicity
Citation
Irving, S., Trotter, M. I., Fallon, J. B., Millard, R. E., Shepherd, R. K., Wise, A. K. (2013). Cochlear implantation for chronic electrical stimulation in the mouse. Hearing Research (306), pp. 37-45.