BI publications


Recent Submissions

Now showing 1 - 5 of 326
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    Integrating Upper-Limb Prostheses with the Human Body: Technology Advances, Readiness, and Roles in Human-Prosthesis Interaction.
    (Annual Review of Biomedical Engineering, 2024-04-09) Huang, He Helen; Hargrove, Levi J; Ortiz-Catalan, Max; Sensinger, Jonathon W
    Significant advances in bionic prosthetics have occurred in the past two decades. The field's rapid expansion has yielded many exciting technologies that can enhance the physical, functional, and cognitive integration of a prosthetic limb with a human. We review advances in the engineering of prosthetic devices and their interfaces with the human nervous system, as well as various surgical techniques for altering human neuromusculoskeletal systems for seamless human-prosthesis integration. We discuss significant advancements in research and clinical translation, focusing on upper limb prosthetics since they heavily rely on user intent for daily operation, although many discussed technologies have been extended to lower limb prostheses as well. In addition, our review emphasizes the roles of advanced prosthetics technologies in complex interactions with humans and the technology readiness levels (TRLs) of individual research advances. Finally, we discuss current gaps and controversies in the field and point out future research directions, guided by TRLs.
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    Neurophysiological correlates of non-motor symptoms in late premanifest and early-stage manifest huntington's disease.
    (Clinical Neurophysiology, 2023-09) Davis, Marie-Claire; Hill, Aron T; Fitzgerald, Paul B; Bailey, Neil W; Stout, Julie C; Hoy, Kate E
    To find sensitive neurophysiological correlates of non-motor symptoms in Huntington's disease (HD), which are essential for the development and assessment of novel treatments.
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    Concurrent transcranial magnetic stimulation and electroencephalography measures are associated with antidepressant response from rTMS treatment for depression
    (Journal of Affective Disorders Reports, 2023-12) Bailey, Neil W; Hoy, Kate E; Sullivan, Caley M; Allman, Brienna; Rogasch, Nigel C; Daskalakis, Zafiris J; Fitzgerald, Paul B
    Background Response rates to repetitive transcranial magnetic stimulation (rTMS) for depression are 25-45%. Participant features obtained prior to treatment that are associated with response to rTMS may be clinically useful. TMS-evoked neural activity recorded via electroencephalography (EEG) prior to treatment may be associated with treatment response. We examined whether these measures could differentiate responders and non-responders to rTMS for depression. Methods Thirty-nine patients with treatment-resistant major depressive disorder (MDD) and 21 healthy controls received TMS during EEG recordings (TMS-EEG). MDD participants then completed 5-8 weeks of rTMS treatment. Repeated measures ANOVAs compared N100 amplitude, N100 slope, and theta power across 3 groups (responders, non-responders and controls), 2 hemispheres (left, F3, and right, F4), and 2 stimulation types (single pulse and paired pulses with a 100ms inter-pulse interval [pp100]). Results Neither N100 amplitude nor theta power differed between responders and non-responders. Responders showed a steeper negative N100 slope for single pulses and steeper positive slope for pp100 pulses at F3 than non-responders. Exploratory analyses suggested this may have been due to the responder group showing larger P60 and N100 amplitudes. Limitations Our study had a small sample size. Conclusion Left hemisphere TEPs, in particular N100 slope, may be related to response rTMS treatment for depression. If our future research with larger sample sizes verifies this result, the finding may provide clinical utility in recommendations for rTMS treatment for depression.
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    Effects of transcranial direct current stimulation and transcranial random noise stimulation on working memory and task-related EEG in major depressive disorder.
    (Brain and Cognition, 2023-12) Murphy, O W; Hoy, K E; Wong, D; Bailey, N W; Fitzgerald, P B; Segrave, R A
    To compare effects of transcranial direct current stimulation (tDCS) and transcranial random noise stimulation with a direct-current offset (tRNS + DC-offset) on working memory (WM) performance and task-related electroencephalography (EEG) in individuals with Major Depressive Disorder (MDD).
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    A comprehensive characterization of cognitive performance, clinical symptoms, and cortical activity following mild traumatic brain injury (mTBI).
    (Applied Neuropsychology: Adult, 2023-11-28) Coyle, Hannah L; Bailey, Neil W; Ponsford, Jennie; Hoy, Kate E
    The objective of this study was to investigate clinical symptoms, cognitive performance and cortical activity following mild traumatic brain injury (mTBI).