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Title: Cochlear implantation for chronic electrical stimulation in the mouse.
Authors: Irving, Samuel
Trotter, Matthew
Fallon, James
Millard, Rodney
Shepherd, Robert
Wise, Andrew
Keywords: Cochlear Implant
Chronic Electrical Stimulation
Fully Implantable
Issue Date: Dec-2013
Publisher: Elsevier
Citation: Irving, S., Trotter, M. I., Fallon, J. B., Millard, R. E., Shepherd, R. K., Wise, A. K. (2013). Cochlear implantation for chronic electrical stimulation in the mouse. Hearing Research (306), pp. 37-45.
Abstract: The mouse is becoming an increasingly attractive model for auditory research due to the number of genetic deafness models available. These genetic models offer the researcher an array of congenital causes of hearing impairment, and are therefore of high clinical relevance. To date, the use of mice in cochlear implant research has not been possible due to the lack of an intracochlear electrode array and stimulator small enough for murine use, coupled with the difficulty of the surgery in this species. Here, we present a fully-implantable intracochlear electrode stimulator assembly designed for chronic implantation in the mouse. We describe the surgical approach for implantation, as well as presenting the first functional data obtained from intracochlear electrical stimulation in the mouse.
URI: http://repository.bionicsinstitute.org:8080/handle/123456789/97
Appears in Collections:Bionic Hearing Research Publications

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