An investigation of dendritic delay in octopus cells of the mammalian cochlear nucleus

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dc.contributor.authorSpencer, Martin
dc.contributor.authorGrayden, David
dc.contributor.authorBruce, Ian
dc.contributor.authorMeffin, Hamish
dc.contributor.authorBurkitt, Anthony
dc.date.accessioned2013-09-23T06:02:08Z
dc.date.available2013-09-23T06:02:08Z
dc.date.issued2012-10-22
dc.description.abstractOctopus cells, located in the mammalian auditory brainstem, receive their excitatory synaptic input exclusively from auditory nerve fibers (ANFs). They respond with accurately timed spikes but are broadly tuned for sound frequency. Since the representation of information in the auditory nerve is well understood, it is possible to pose a number of question about the relationship between the intrinsic electrophysiology, dendritic morphology, synaptic connectivity, and the ultimate functional role of octopus cells in the brainstem. This study employed a multi-compartmental Hodgkin-Huxley model to determine whether dendritic delay in octopus cells improves synaptic input coincidence detection in octopus cells by compensating for the cochlear traveling wave delay. The propagation time of post-synaptic potentials from synapse to soma was investigated. We found that the total dendritic delay was approximately 0.275 ms. It was observed that low-threshold potassium channels in the dendrites reduce the amplitude dependence of the dendritic delay of post-synaptic potentials. As our hypothesis predicted, the model was most sensitive to acoustic onset events, such as the glottal pulses in speech when the synaptic inputs were arranged such that the models dendritic delay compensated for the cochlear travelling wave delay across the ANFs. The range of sound frequency input from ANFs was also investigated. The results suggested that input octopus cells is dominated by high frequency ANfs.en_US
dc.description.sponsorshipNHMRC (567164); NICTA; ARC (DP1094830); NICTA funded by Australian Government Department of Broadband, Communications and the Digital Economy through the ICT Centre of Excellence Program, Victorian Government through its Operational Infrastructure Program. [This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.]en_US
dc.identifier.citationSpencer, M. J., Grayden, D. B., Bruce, I. C., Meffin, H., & Burkitt, A. N. (2012). An investigation of dentritic delay in octopus cells of the mammalian cochlear nucleus. Frontiers in Computational Neuroscience, 6. doi: 10.3389/fncom.2012.00083 [This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.]en_US
dc.identifier.issn1662-5188
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/48
dc.language.isoenen_US
dc.publisherFrontiers in Computational Neuroscienceen_US
dc.subjectAuditoryen_US
dc.subjectCochlear nucleusen_US
dc.subjectComputational modelen_US
dc.subjectConnectivityen_US
dc.subjectOctopusen_US
dc.subjectCellsen_US
dc.subjectAuditory-nerve fibersen_US
dc.subjectPhysiologically characterized cellsen_US
dc.subjectThresholden_US
dc.subjectPotassium channelen_US
dc.subjectActivated cation currenten_US
dc.subjectAxon initial segmenten_US
dc.subjectMathematical-modelsen_US
dc.subjectProjection patternsen_US
dc.subjectResponseen_US
dc.subjectPropertiesen_US
dc.subjectCortical-neuronsen_US
dc.titleAn investigation of dendritic delay in octopus cells of the mammalian cochlear nucleusen_US
dc.typeArticleen_US
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