Laminin coated diamond electrodes for neural stimulation

Simple item page
dc.contributor.authorSikder, Md..Kabir Uddin
dc.contributor.authorTong, Wei
dc.contributor.authorPingle, Hitesh
dc.contributor.authorKingshott, Peter
dc.contributor.authorNeedham, Karina
dc.contributor.authorShivdasani, Mohit
dc.contributor.authorFallon, James
dc.contributor.authorSeligman, Peter
dc.contributor.authorIbbotson, Michael
dc.contributor.authorPrawer, Steven
dc.contributor.authorGarrett, David
dc.date.accessioned2020-10-05T01:00:23Z
dc.date.available2020-10-05T01:00:23Z
dc.date.issued2020-09
dc.description.abstractThe performance of many implantable neural stimulation devices is degraded due to the loss of neurons around the electrodes by the body's natural biological responses to a foreign material. Coating of electrodes with biomolecules such as extracellular matrix proteins is one potential route to suppress the adverse responses that lead to loss of implant functionality. Concurrently, however, the electrochemical performance of the stimulating electrode must remain optimal to continue to safely provide sufficient charge for neural stimulation. We have previously found that oxygen plasma treated nitrogen included ultrananocrystalline diamond coated platinum electrodes exhibit superior charge injection capacity and electrochemical stability for neural stimulation (Sikder et al., 2019). To fabricate bioactive diamond electrodes, in this work, laminin, an extracellular matrix protein known to be involved in inter-neuron adhesion and recognition, was used as an example biomolecule. Here, laminin was covalently coupled to diamond electrodes. Electrochemical analysis found that the covalently coupled films were robust and resulted in minimal change to the charge injection capacity of diamond electrodes. The successful binding of laminin and its biological activity was further confirmed using primary rat cortical neuron cultures, and the coated electrodes showed enhanced cell attachment densities and neurite outgrowth. The method proposed in this work is versatile and adaptable to many other biomolecules for producing bioactive diamond electrodes, which are expected to show reduced the inflammatory responses in vivo.en_US
dc.description.sponsorshipWT is supported by a Medical/Science Grant from the CASS Foundation. DJG is supported by the National Health and Medical Research Council (NHMRC) of Australia, grant GNT1101717. The Australian Research Council (ARC) is acknowledged for funding a Ph.D. scholarship for HP through a Discovery Project (DP120103405).en_US
dc.identifier.citationSikder, K. U., W. Tong, H. Pingle, P. Kingshott, K. Needham, M. N. Shivdasani, J. B. Fallon, P. Seligman, M. R. Ibbotson, and S. Prawer. 2020. Laminin coated diamond electrodes for neural stimulation. Materials Science and Engineering: C: 111454.en_US
dc.identifier.issn0928-4931
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/409
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.subjectDiamond electrodeen_US
dc.subjectLaminin coatingen_US
dc.subjectBiocompatibilityen_US
dc.subjectNeural stimulationen_US
dc.subjectCharge injection capacityen_US
dc.titleLaminin coated diamond electrodes for neural stimulationen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2020_Sikder_Laminin.pdf
Size:
56.86 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
BI publications