Nanoporous peptide particles for encapsulating and releasing neurotrophic factors in an animal model of neurodegeneration.

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dc.contributor.authorTan, Justin
dc.contributor.authorWang, Yajun
dc.contributor.authorYip, Xiaopei
dc.contributor.authorGlynn, Fergal
dc.contributor.authorShepherd, Robert
dc.contributor.authorCaruso, Frank
dc.date.accessioned2014-04-01T02:08:40Z
dc.date.available2014-04-01T02:08:40Z
dc.date.issued2012-07
dc.description.abstractNeurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons in the cochlea of guinea pigs with sensorineural hearing loss.en_US
dc.description.sponsorshipThis work was supported by the National Health and Medical Research Council (NHMRC) Project Grant APP1005071 (R.K.S., F.C., J.T., Y.W.), by the Australian Research Council under the Federation Fellowship scheme (F.C.), the Royal Victorian Eye and Ear Hospital (F.G.) and the National Institutes of Health (USA) HHS-N-263-2007-00053-C (R.K.S.). The Bionics Institute acknowledges the support it receives from the Victorian government through its Operational Infrastructure Support Program.en_US
dc.identifier.citationTan, J., Wang, Y., Yip, X., Glynn, F., Shepherd, R. K. & Caruso, F. (2012). Nanoporous peptide particles for encapsulating and releasing neurotrophic factors in an animal model of neurodegeneration. Advanced Materials 24, pp. 3362-3366.en_US
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/74
dc.language.isoenen_US
dc.publisherWiley Onlineen_US
dc.titleNanoporous peptide particles for encapsulating and releasing neurotrophic factors in an animal model of neurodegeneration.en_US
dc.typeArticleen_US
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