Nanoporous peptide particles for encapsulating and releasing neurotrophic factors in an animal model of neurodegeneration.
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Date
2012-07
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Wiley Online
Abstract
Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons in the cochlea of guinea pigs with sensorineural hearing loss.
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Citation
Tan, J., Wang, Y., Yip, X., Glynn, F., Shepherd, R. K. & Caruso, F. (2012). Nanoporous peptide particles for encapsulating and releasing neurotrophic factors in an animal model of neurodegeneration. Advanced Materials 24, pp. 3362-3366.