Influence of cochleostomy and cochlear implant insertion on drug gradients following intratympanic application in guinea pigs

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dc.contributor.authorKing, Elisha
dc.contributor.authorHartsock, Jared
dc.contributor.authorO'Leary, Stephen
dc.contributor.authorSalt, Alec
dc.date.accessioned2013-11-17T22:11:49Z
dc.date.available2013-11-17T22:11:49Z
dc.date.issued2013-09
dc.description.abstractLocally applied drugs can protect residual hearing following cochlear implantation. The influence of cochlear implantation on drug levels in the scala tympani (ST) after round window application was investigated in guinea pigs using the marker trimethylphenylammonium (TMPA) measured in real time with TMPA-selective microelectrodes. TMPA concentration in the upper basal turn of the ST rapidly increased during implantation and then declined due to cerebrospinal fluid entering the ST at the cochlear aqueduct and exiting at the cochleostomy. The TMPA increase was found to be caused by the cochleostomy drilling if the burr tip partially entered the ST. TMPA distribution in the second turn was less affected by implantation procedures. These findings show that basal turn drug levels may be changed during implantation and the changes may need to be considered in the interpretation of therapeutic effects of drugs in conjunction with implantation.en_US
dc.description.sponsorshipNIH/NIDCD grant DC01368, NHMRC grant 1007948en_US
dc.identifier.citationKing, E. B., Hartsock, J. J., O'Leary, S. J., & Salt, A. N. (2013). Influence of cochleostomy and cochlear implant insertion on drug gradients following intratympanic application in guinea pigs. Audiol Neurotol, 18(5), 307-316. doi: 10.1159/000353534en_US
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/62
dc.language.isoenen_US
dc.publisherKarger Medical and Scientific Publishersen_US
dc.subjectCochleostomyen_US
dc.subjectPerforationen_US
dc.subjectCochlear Implanten_US
dc.subjectElectrodeen_US
dc.subjectPharmokineticsen_US
dc.subjectDrug Distributionen_US
dc.subjectComputational Modellingen_US
dc.titleInfluence of cochleostomy and cochlear implant insertion on drug gradients following intratympanic application in guinea pigsen_US
dc.typeArticleen_US
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