Human stem cells ameliorate auditory evoked responses in a model of neuropathy
| dc.contributor.author | Nayagam, Bryony | |
| dc.date.accessioned | 2014-04-01T01:39:50Z | |
| dc.date.available | 2014-04-01T01:39:50Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | Stem cells have been touted as a potential source of replacement cells for the treatment of severe- to-profoundly deaf individuals, including possible combined therapy with a cochlear implant. The success of such a therapy is dependent on a number of factors, but of critical importance is the functional incorporation of transplanted cells into the peripheral and central auditory systems. In a major breakthrough, Chen and colleagues recently reported the restoration of hearing thresholds by up to 46% following the transplantation of human pluripotent stem cells in a rodent auditory neuropathy model. Improved function was matched with new synapse formation in the peripheral and central aspects of the auditory system. The fi ndings have promising clinical implications for patients with auditory neuropathy. Still to be elucidated are the long-term survival and function of transplanted cells, the precise mechanism by which hearing is restored, and whether further improvement is possible when combined with electrical stimulation from a cochlear implant. | en_US |
| dc.description.sponsorship | BAN is supported by an Australian-Based Biomedical Fellowship from the National Health and Medical Research Council of Australia. Aspects of this work have been fi nancially supported by the University of Melbourne Department of Otolaryngology, the Royal Victorian Eye and Ear Hospital, the Bionics Institute, and project grants from the National Health and Medical Research Council of Australia and the Garnett Passe and Rodney Williams Memorial Foundation. | en_US |
| dc.identifier.citation | Nayagam, B. A. (2012). Human stem cells ameliorate auditory evoked responses in a model of neuropathy. Stem Cell Research & Therapy, 3. doi: 4410.1186/scrt135 | en_US |
| dc.identifier.uri | http://repository.bionicsinstitute.org:8080/handle/123456789/73 | |
| dc.language.iso | en | en_US |
| dc.publisher | BioMed Central Ltd | en_US |
| dc.title | Human stem cells ameliorate auditory evoked responses in a model of neuropathy | en_US |
| dc.type | Article | en_US |