Human stem cells ameliorate auditory evoked responses in a model of neuropathy

Abstract

Stem cells have been touted as a potential source

of replacement cells for the treatment of severe-

to-profoundly deaf individuals, including possible

combined therapy with a cochlear implant. The

success of such a therapy is dependent on a number

of factors, but of critical importance is the functional

incorporation of transplanted cells into the peripheral

and central auditory systems. In a major breakthrough,

Chen and colleagues recently reported the restoration

of hearing thresholds by up to 46% following the

transplantation of human pluripotent stem cells in a

rodent auditory neuropathy model. Improved function

was matched with new synapse formation in the

peripheral and central aspects of the auditory system.

The fi ndings have promising clinical implications

for patients with auditory neuropathy. Still to be

elucidated are the long-term survival and function of

transplanted cells, the precise mechanism by which

hearing is restored, and whether further improvement

is possible when combined with electrical stimulation

from a cochlear implant.