Mold-Templated Inorganic−Organic Hybrid Supraparticles for Codelivery of Drugs
Loading...
Date
2014-10
Journal Title
Journal ISSN
Volume Title
Publisher
ACS Publications
Abstract
This paper reports a facile and robust moldtemplated
technique for the assembly of mesoporous silica
(MS) supraparticles and demonstrates their potential as
vehicles for codelivery of brain-derived neurotrophic factor
(BDNF) and dexamethasone (DEX). The MS supraparticles
are assembled using gelatin as a biodegradable adhesive to bind
and cross-link the particles. Microfabricated molds made of
polydimethylsiloxane are used to control the size and shape of
the supraparticles. The obtained mesoporous silica-gelatin
hybrid supraparticles (MSG-SPs) are stable in water as well as
in organic solvents, such as dimethyl sulfoxide, and efficiently coencapsulate both BDNF and DEX. The MSG-SPs also exhibit
sustained release kinetics in simulated physiological conditions (>30 days), making them potential candidates for long-term
delivery of therapeutics to the inner ear.
Description
Keywords
Drug Delivery, Neurotrophins, Supraparticles
Citation
Maina JW, Cui J, Bjornmalm M, Wise AK, Shepherd RK, Caruso F (2014). Mold-templated inorganic-organic hybrid supraparticles for codelivery of drugs. Biomacromolecules 15, 4146-4151.