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Title: Mold-Templated Inorganic−Organic Hybrid Supraparticles for Codelivery of Drugs
Authors: Maina, James
Cui, Jiwei
Bjornmalm, Mattias
Wise, Andrew
Shepherd, Robert
Caruso, Frank
Keywords: Drug Delivery
Neurotrophins
Supraparticles
Issue Date: Oct-2014
Publisher: ACS Publications
Citation: Maina JW, Cui J, Bjornmalm M, Wise AK, Shepherd RK, Caruso F (2014). Mold-templated inorganic-organic hybrid supraparticles for codelivery of drugs. Biomacromolecules 15, 4146-4151.
Abstract: This paper reports a facile and robust moldtemplated technique for the assembly of mesoporous silica (MS) supraparticles and demonstrates their potential as vehicles for codelivery of brain-derived neurotrophic factor (BDNF) and dexamethasone (DEX). The MS supraparticles are assembled using gelatin as a biodegradable adhesive to bind and cross-link the particles. Microfabricated molds made of polydimethylsiloxane are used to control the size and shape of the supraparticles. The obtained mesoporous silica-gelatin hybrid supraparticles (MSG-SPs) are stable in water as well as in organic solvents, such as dimethyl sulfoxide, and efficiently coencapsulate both BDNF and DEX. The MSG-SPs also exhibit sustained release kinetics in simulated physiological conditions (>30 days), making them potential candidates for long-term delivery of therapeutics to the inner ear.
URI: http://repository.bionicsinstitute.org:8080/handle/123456789/100
Appears in Collections:Bionic Hearing Research Publications

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