Vagus nerve stimulation to treat inflammatory bowel disease: a chronic, preclinical safety study in sheep

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dc.contributor.authorPayne, Sophie
dc.contributor.authorBurns, Owen
dc.contributor.authorStebbing, Martin
dc.contributor.authorThomas, Ross
dc.contributor.authorde Silva, Angel
dc.contributor.authorSedo, Alicia
dc.contributor.authorWeissenborn, Frank
dc.contributor.authorHyakumura, Tomoko
dc.contributor.authorHuynh, Mario
dc.contributor.authorMay, Clive
dc.contributor.authorWilliams, Richard
dc.contributor.authorFurness, John
dc.contributor.authorFallon, James
dc.contributor.authorShepherd, Robert
dc.date.accessioned2020-02-03T01:00:29Z
dc.date.available2020-02-03T01:00:29Z
dc.date.issued2019-02
dc.description.abstractAim: Electrical stimulation of the left cervical vagus nerve is a feasible therapy for inflammatory bowel disease (IBD). However, due to the location of the electrode placement, stimulation is often associated with side effects. Methods: We developed a cuff electrode array, designed to be implanted onto the vagus nerve of the lower thorax or abdomen, below branches to vital organs, to minimize off-target effects to stimulation. Results: Following chronic implantation and electrical stimulation, electrodes remained functional and neural thresholds stable, while there were minimal off-target affects to stimulation. No nerve damage or corrosion of stimulated electrodes was observed. Conclusion: This novel electrode array, located on the vagus nerve below branches to vital organs, is a safe approach for the treatment of inflammatory bowel disease.en_US
dc.description.sponsorshipThis work was funded by the Defense Advanced Research Projects Agency (DARPA) BTO, under the auspices of D Weber and EV Gieson through the Space and Naval Warfare Systems Center (Contract no. N66001-15-2-4060). The Bionics Institute and the Florey Institute of Neuroscience and Mental Health acknowledge the support they receive from the Victorian Government through its Operational Infrastructural Support Programen_US
dc.identifier.citationPayne, S. C., O. Burns, M. J. Stebbing, R. Thomas, A. C. de Silva, A. Sedo, F. Wiessenborn, T. Hyakumura, M. Huynh, C. N. May, R. A. Williams, J. Furness, J. Fallon, and R. Shepherd. 2019. Vagus nerve stimulation to treat inflammatory bowel disease: a chronic, preclinical safety study in sheep. Bioelectronics in Medicine. 1(4): 235-250.en_US
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/380
dc.language.isoenen_US
dc.publisherFuture Medicineen_US
dc.subjectElectrode arrayen_US
dc.subjectInflammatory bowel diseaseen_US
dc.subjectPeripheral nerveen_US
dc.subjectVagus nerve stimulationen_US
dc.titleVagus nerve stimulation to treat inflammatory bowel disease: a chronic, preclinical safety study in sheepen_US
dc.typeArticleen_US
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