Infrared neural stimulation fails to evoke neural activity in the deaf guinea pig cochlea.
| dc.contributor.author | Thompson, Alexander | |
| dc.contributor.author | Fallon, James | |
| dc.contributor.author | Wise, Andrew | |
| dc.contributor.author | Wade, Scott | |
| dc.date.accessioned | 2016-03-15T22:31:50Z | |
| dc.date.available | 2016-03-15T22:31:50Z | |
| dc.date.issued | 2015-03 | |
| dc.description.abstract | At present there is some debate as to the processes by which infrared neural stimulation (INS) activates neurons in the cochlea, as the lasers used for INS can potentially generate a range of secondary stimuli e.g. an acoustic stimulus is produced when the light is absorbed by water. To clarify whether INS in the cochlea requires functioning hair cells and to explore the potential relevance to cochlear implants, experiments using INS were performed in the cochleae of both normal hearing and profoundly deaf guinea pigs. A response to laser stimulation was readily evoked in normal hearing cochlea. However, no response was evoked in any profoundly deaf cochleae, for either acute or chronic deafening, contrary to previous work where a response was observed after acute deafening with ototoxic drugs. A neural response to electrical stimulation was readily evoked in all cochleae after deafening. The absence of a response from optical stimuli in profoundly deaf cochleae suggests that the response from INS in the cochlea is hair cell mediated. | en_US |
| dc.description.sponsorship | This work was supported by Cochlear Ltd and the Australian Research Council under grant LP120100264. The Bionics Institute acknowledges the nancial support it receives from the Victorian State Government. | en_US |
| dc.identifier.citation | Thompson, A. C., Fallon, J. B., Wise, A. K., Wade, S. A., Shepherd, R. K., & Stoddart, P. R. (2015). Infrared neural stimulation fails to evoke neural activity in the deaf guinea pig cochlea. Hearing Research, 324, 46-53. | en_US |
| dc.identifier.issn | 0378-5955 | |
| dc.identifier.uri | http://repository.bionicsinstitute.org:8080/handle/123456789/195 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.ispartofseries | 324; | |
| dc.subject | infrared neural stimulation | en_US |
| dc.subject | INS | en_US |
| dc.subject | cochlear implant | en_US |
| dc.subject | optical stimulation | en_US |
| dc.subject | optoacoustic | en_US |
| dc.title | Infrared neural stimulation fails to evoke neural activity in the deaf guinea pig cochlea. | en_US |
| dc.type | Article | en_US |