Neural Electrodes Based on 3D Organic Electroactive Microfibers.

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dc.contributor.authorMarroquin, Jason
dc.contributor.authorColeman, Harold
dc.contributor.authorTonta, Mary
dc.contributor.authorWinther-Jensen, Bjorn
dc.contributor.authorFallon, James
dc.contributor.authorDuffy, Noel
dc.contributor.authorYan, Edwin
dc.contributor.authorAbdulwahid, Ammar
dc.contributor.authorJasieniak, Jacek
dc.contributor.authorForsythe, John
dc.contributor.authorParkington, Helena
dc.date.accessioned2018-08-01T04:12:25Z
dc.date.available2018-08-01T04:12:25Z
dc.date.issued2017-08
dc.description.abstractNeural electrodes used for in vivo biomedical applications (e.g., prostheses, bionic implants) result in glial invasion, leading to the formation of a nonexcitable scar that increases the distance between neurons and electrode and increases the resistance to current flow. The result is progressive deterioration in the performance of stimulation or recording of neural activity and inevitable device failure. Also, electrodes with a 2D surface have a limited proximity to neurons. In the present study, a macroporous and fibrous 3D neural electrode is developed using poly-L-lactic acid fibrous membranes imbued with electroactive properties via a coating of the conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT), using vapor phase polymerization. The electrical properties of the PEDOT-coated substrates are studied using sheet resistance and impedance. PEDOT electrode biocompatibility is assessed through in vitro assays using patch-clamp electrophysiology and calcium imaging of isolated and cultured rat hippocampal neurons. PEDOT fibers support robust normal functional development of neurons, including synaptic networking and communication. Stimulation and recording of activity in brain slices and from the surface of the brain using 3D-PEDOT fibrous electrodes are indistinguishable from recordings using conventional glass or platinum electrodes. In vivo studies reveal minimal reactive gliosis in response to electrode implantation.en_US
dc.description.sponsorshipThis project was supported by the Australian Research Council Discovery Project DP140100803, awarded to J.S.F. and H.C.P. The authors acknowledge use of the facilities within the Monash Centre for Electron Microscopy and Monash Micro Imaging. The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program.en_US
dc.identifier.citationMarroquin, Jason B., Harold A. Coleman, Mary A. Tonta, Kun Zhou, Bjorn Winther-Jensen, James Fallon, Noel W. Duffy, Edwin Yan, Ammar A. Abdulwahid, Jacek J. Jasieniak, John S. Forsythe, and Helena C. Parkington. 2017. Neural Electrodes Based on 3D Organic Electroactive Microfibers. Advanced Functional Materials: 1700927.en_US
dc.identifier.issn1616-3028
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/311
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectElectrophysiologyen_US
dc.subjectNeural electrodesen_US
dc.subjectNeural interfacesen_US
dc.subjectpoly(3,4-ethylenedioxythiophene) (PEDOT)en_US
dc.titleNeural Electrodes Based on 3D Organic Electroactive Microfibers.en_US
dc.typeArticleen_US
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