Electrochemical and mechanical performance of reduced graphene oxide, conductive hydrogel, and electrodeposited Pt-Ir coated electrodes: an active in vitro study

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dc.contributor.authorDalrymple, Ashley
dc.contributor.authorHuynh, Mario
dc.contributor.authorRobles, Ulyises
dc.contributor.authorMarroquin, Jason
dc.contributor.authorLee, Curtis
dc.contributor.authorPetrossians, Artin
dc.contributor.authorWhalen, John
dc.contributor.authorLi, Dan
dc.contributor.authorParkington, Helena
dc.contributor.authorForsythe, John
dc.contributor.authorGreen, Rylie
dc.contributor.authorPoole-Warren, Laura
dc.contributor.authorShepherd, Robert
dc.contributor.authorFallon, James
dc.date.accessioned2019-10-29T23:59:16Z
dc.date.available2019-10-29T23:59:16Z
dc.date.issued2019-10
dc.description.abstractOBJECTIVE: To systematically compare the in vitro electrochemical and mechanical properties of several electrode coatings that have been reported to increase the efficacy of medical bionics devices by increasing the amount of charge that can be delivered safely to the target neural tissue. APPROACH: Smooth platinum (Pt) ring and disc electrodes were coated with reduced graphene oxide, conductive hydrogel, or electrodeposited Pt-Ir. Electrodes with coatings were compared with uncoated smooth Pt electrodes before and after an in vitro accelerated aging protocol. The various coatings were compared mechanically using the adhesion-by-tape test. Electrodes were stimulated in saline for 24 hours/day 7 days/week for 21 days at 85 masculineC (1.6-year equivalence) at a constant charge density of 200 muC/cm2/phase. Electrodes were graded on surface corrosion and trace analysis of Pt in the electrolyte after aging. Electrochemical measurements performed before, during, and after aging included electrochemical impedance spectroscopy, cyclic voltammetry, and charge injection limit and impedance from voltage transient recordings. MAIN RESULTS: All three coatings adhered well to smooth Pt and exhibited electrochemical advantage over smooth Pt electrodes prior to aging. After aging, graphene coated electrodes displayed a stimulation-induced increase in impedance and reduction in the charge injection limit (p < 0.001), alongside extensive corrosion and release of Pt into the electrolyte. In contrast, both conductive hydrogel and Pt-Ir coated electrodes had smaller impedances and larger charge injection limits than smooth Pt electrodes (p < 0.001) following aging regardless of the stimulus level and with little evidence of corrosion or Pt dissolution. SIGNIFICANCE: This study rigorously tested the mechanical and electrochemical performance of electrode coatings in vitro and provided suitable candidates for future in vivo testing.en_US
dc.description.sponsorshipThis work was funded by the NHMRC of the Australian Government (APP1122055) and the Garnett Passe and Rodney Williams Memorial Foundation for which we are most grateful. The Bionics Institute acknowledges support of the Victorian Government through Operational Infrastructure Support Program.en_US
dc.identifier.citationDalrymple, A. N., M. Huynh, U. A. Aregueta Robles, J. B. Marroquin, C. Lee, A. Petrossians, J. J. Whalen, D. Li, H. C. Parkington, J. S. Forsythe, R. Green, L. A. Poole-Warren, R. K. Shepherd, and J. B. Fallon. 2019. Electrochemical and mechanical performance of reduced graphene oxide, conductive hydrogel, and electrodeposited Pt-Ir coated electrodes: an active in vitro study. Journal of Neural Engineering. 17(1): 016015.en_US
dc.identifier.issn1741-2552
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/370
dc.language.isoenen_US
dc.publisherIOP Publishingen_US
dc.subjectElectrical stimulationen_US
dc.subjectNeural prosthesisen_US
dc.subjectElectrodeen_US
dc.subjectIn vitroen_US
dc.subjectPlatinumen_US
dc.subjectConductive hydrogelen_US
dc.subjectReduced graphene oxideen_US
dc.subjectElectrodeposited Pt-Iren_US
dc.subjectCorrosionen_US
dc.titleElectrochemical and mechanical performance of reduced graphene oxide, conductive hydrogel, and electrodeposited Pt-Ir coated electrodes: an active in vitro studyen_US
dc.typeArticleen_US
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