Improved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochlea

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dc.contributor.authorWise, Andrew
dc.contributor.authorTan, Justin
dc.contributor.authorWang, Yajun
dc.contributor.authorCaruso, Frank
dc.contributor.authorShepherd, Robert
dc.date.accessioned2016-11-02T04:48:49Z
dc.date.available2016-11-02T04:48:49Z
dc.date.issued2016-10
dc.description.abstractCochlear implants electrically stimulate spiral ganglion neurons (SGNs) in order to provide speech cues to severe-profoundly deaf patients. In normal hearing cochleae the SGNs depend on endogenous neurotrophins secreted by sensory cells in the organ of Corti for survival. SGNs gradually degenerate following deafness and consequently there is considerable interest in developing clinically relevant strategies to provide exogenous neurotrophins to preserve SGN survival. The present study investigated the safety and efficacy of a drug delivery system for the cochlea using nanoengineered silica supraparticles. In the present study we delivered Brain-derived neurotrophic factor (BDNF) over a period of four weeks and evaluated SGN survival as a measure of efficacy. Supraparticles were bilaterally implanted into the basal turn of cochleae in profoundly deafened guinea pigs. One ear received BDNF-loaded supraparticles and the other ear control (unloaded) supraparticles. After one month of treatment the cochleae were examined histologically. There was significantly greater survival of SGNs in cochleae that received BDNF supraparticles compared to the contralateral control cochleae (repeated measures ANOVA, p = 0.009). SGN survival was observed over a wide extent of the cochlea. The supraparticles were well tolerated within the cochlea with a tissue response that was localised to the site of implantation in the cochlear base. Although mild, the tissue response was significantly greater in cochleae treated with BDNF supraparticles compared to the controls (repeated measures ANOVA, p = 0.003). These data support the clinical potential of this technology particularly as the supraparticles can be loaded with a variety of therapeutic drugs.en_US
dc.description.sponsorshipThis work was funded by National Health and Medical Research Council Project Grant APP1005071 and APP1064375, Australian Research Council under the Australian Laureate Fellowship scheme (120100030), and National Institutes of Health (USA) HHS-N-263-2007-00053-C.en_US
dc.identifier.citationWise, A. K., Tan, J., Wang, Y., Caruso, F. and Shepherd, R.K. (2016). Improved auditory nerve survival with nanoengineered supraparticles for neurotrophin delivery into the deafened cochlea. Plos One, 11(10).en_US
dc.identifier.issn1932-6203 (Electronic) 1932-6203 (Linking)
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/221
dc.language.isoenen_US
dc.publisherPloS Oneen_US
dc.subjectauditory nerveen_US
dc.subjectnanoparticlesen_US
dc.subjectcochleaen_US
dc.titleImproved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochleaen_US
dc.typeArticleen_US
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