Oculomotor Responses to Dynamic Stimuli in a 44-Channel Suprachoroidal Retinal Prosthesis

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dc.contributor.authorTitchener, Samuel
dc.contributor.authorKvansakul, Jessica
dc.contributor.authorShivdasani, Mohit
dc.contributor.authorNayagam, David
dc.contributor.authorEpp, Stephanie
dc.contributor.authorWilliams, Chris
dc.contributor.authorBarnes, Nick
dc.contributor.authorKentler, William
dc.contributor.authorKolic, Maria
dc.contributor.authorBalin, Elizabeth
dc.contributor.authorAyton, Lauren
dc.contributor.authorAbbott, Carla
dc.contributor.authorLuu, Chi
dc.contributor.authorAllen, Penelope
dc.contributor.authorPetoe, Matthew
dc.date.accessioned2021-02-08T04:34:15Z
dc.date.available2021-02-08T04:34:15Z
dc.date.issued2020-12
dc.description.abstractPURPOSE: To investigate oculomotor behavior in response to dynamic stimuli in retinal implant recipients. METHODS: Three suprachoroidal retinal implant recipients performed a four-alternative forced-choice motion discrimination task over six sessions longitudinally. Stimuli were a single white bar ("moving bar") or a series of white bars ("moving grating") sweeping left, right, up, or down across a 42″ monitor. Performance was compared with normal video processing and scrambled video processing (randomized image-to-electrode mapping to disrupt spatiotemporal structure). Eye and head movement was monitored throughout the task. RESULTS: Two subjects had diminished performance with scrambling, suggesting retinotopic discrimination was used in the normal condition and made smooth pursuit eye movements congruent to the moving bar stimulus direction. These two subjects also made stimulus-related eye movements resembling optokinetic reflex (OKR) for moving grating stimuli, but the movement was incongruent with stimulus direction. The third subject was less adept at the task, appeared primarily reliant on head position cues (head movements were congruent to stimulus direction), and did not exhibit retinotopic discrimination and associated eye movements. CONCLUSIONS: Our observation of smooth pursuit indicates residual functionality of cortical direction-selective circuits and implies a more naturalistic perception of motion than expected. A distorted OKR implies improper functionality of retinal direction-selective circuits, possibly due to retinal remodeling or the non-selective nature of the electrical stimulation. TRANSLATIONAL RELEVANCE: Retinal implant users can make naturalistic eye movements in response to moving stimuli, highlighting the potential for eye tracker feedback to improve perceptual localization and image stabilization in camera-based visual prostheses.en_US
dc.description.sponsorshipSupported by the Clive and Vera Ramaciotti Foundation (MAP; Health Investment Grant), the Bertalli Family Foundation to the Bionics Institute, the National Health and Medical Research Council (grant 1082358 to CIA A/Prof Allen), and by the Melbourne Neuroscience Institute Australian Government Research Training Program (SAT). The Bionics Institute and the Centre for Eye Research Australia receive support from the Victorian Government through its Operational Infrastructure Program.DN, MP, ST, KY MK, EB, CA, CL, JK, WK, CW, NB, PA receive(d) funding support from Bionic Vision Technologies.en_US
dc.identifier.citationTitchener, S. A., J. Kvansakul, M. N. Shivdasani, J. B. Fallon, D. A. X. Nayagam, S. B. Epp, C. E. Williams, N. Barnes, W. G. Kentler, M. Kolic, E. K. Baglin, L. N. Ayton, C. J. Abbott, C. D. Luu, P. J. Allen, and M. A. Petoe. 2020. Oculomotor Responses to Dynamic Stimuli in a 44-Channel Suprachoroidal Retinal Prosthesis. Translational Vision Science & Technology. 9(13): 31.en_US
dc.identifier.issn2164-2591
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/413
dc.language.isoenen_US
dc.publishertvsten_US
dc.subjectVisual prosthesisen_US
dc.subjectRetinal prosthesisen_US
dc.subjectMotion perceptionen_US
dc.subjectEye movementsen_US
dc.subjectHead movementsen_US
dc.titleOculomotor Responses to Dynamic Stimuli in a 44-Channel Suprachoroidal Retinal Prosthesisen_US
dc.typeArticleen_US
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