The dynamic relationship between cerebellar Purkinje cell simple spikes and the spikelet number of complex spikes

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dc.contributor.authorBurroughs, Amelia
dc.contributor.authorWise, Andrew
dc.contributor.authorXiao, Jianqiang
dc.contributor.authorHoughton, Conor
dc.contributor.authorTang, Tianyu
dc.contributor.authorSuh, Colleen
dc.contributor.authorLang, Eric J
dc.contributor.authorApps, Richard
dc.contributor.authorCerminara, Nadia L
dc.date.accessioned2018-01-09T04:17:16Z
dc.date.available2018-01-09T04:17:16Z
dc.date.issued2017-01
dc.description.abstractPurkinje cells are central to cerebellar function because they form the sole output of the cerebellar cortex. They exhibit two distinct types of action potential: simple spikes and complex spikes. It is widely accepted that interaction between these two types of impulse is central to cerebellar cortical information processing. Previous investigations of the interactions between simple spikes and complex spikes have mainly considered complex spikes as unitary events. However, complex spikes are composed of an initial large spike followed by a number of secondary components, termed spikelets. The number of spikelets within individual complex spikes is highly variable and the extent to which differences in complex spike spikelet number affects simple spike activity (and vice versa) remains poorly understood. In anaesthetized adult rats, we have found that Purkinje cells recorded from the posterior lobe vermis and hemisphere have high simple spike firing frequencies that precede complex spikes with greater numbers of spikelets. This finding was also evident in a small sample of Purkinje cells recorded from the posterior lobe hemisphere in awake cats. In addition, complex spikes with a greater number of spikelets were associated with a subsequent reduction in simple spike firing rate. We therefore suggest that one important function of spikelets is the modulation of Purkinje cell simple spike firing frequency, which has implications for controlling cerebellar cortical output and motor learning.en_US
dc.description.sponsorshipThis work was supported by the MRC (RA, NLC), Wellcome Trust (AB, AKW, CH, RA) and the National Science Foundation (JX, TT, CH, EJL).en_US
dc.identifier.citationBurroughs, A., A. K. Wise, J. Q. Xiao, C. Houghton, T. Y. Tang, C. Y. Suh, E. J. Lang, R. Apps, and N. L. Cerminara. 2017. The dynamic relationship between cerebellar Purkinje cell simple spikes and the spikelet number of complex spikes. Journal of Physiology-London. 595(1): 283-99.en_US
dc.identifier.issn0022-3751
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/275
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltden_US
dc.subjectCerebellumen_US
dc.subjectPurkinje cellen_US
dc.subjectIn vivoen_US
dc.titleThe dynamic relationship between cerebellar Purkinje cell simple spikes and the spikelet number of complex spikesen_US
dc.typeArticleen_US
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