Spatiotemporal interactions in the visual cortex following paired electrical stimulation of the retina

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dc.contributor.authorCicione, Rosemary
dc.contributor.authorFallon, James
dc.contributor.authorRathbone, Graeme
dc.contributor.authorWilliams, Chris
dc.contributor.authorShivdasani, Mohit
dc.date.accessioned2015-05-04T04:08:56Z
dc.date.available2015-05-04T04:08:56Z
dc.date.issued2014-11
dc.description.abstractPURPOSE: Retinal prostheses use spatiotemporal patterns of electrical stimulation across multiple electrodes to provide visual percepts to blind patients. It is generally assumed that percepts produced by individual electrodes are independent of one another, which may not be the case. In this study, we aimed to quantify interactions between pairs of electrical stimuli delivered to the retina. METHODS: Normally sighted cats were implanted with a suprachoroidal electrode array. The retina was stimulated with a paired-pulse paradigm that consisted of a conditioning stimulus followed by a test stimulus, while recording multiunit activity in the visual cortex. Conditioning current, and spatial and temporal separation between the conditioning and test stimuli were varied. Cortical interactions were quantified by changes in multiunit activity elicited by stimulation with the paired-pulse paradigm, compared to stimulation of the test stimulus alone (control). RESULTS: Interactions varied as a function of conditioning current and temporal separation between the two stimulating pulses. Cortical activity increased compared to the control condition at an interstimulus delay of 1.025 ms and was significantly suppressed for delays between 20 and 90 ms, returning to near control levels for longer delays. The level of interactions increased when the conditioning current was increased. Interactions were found to be similar for electrode separations up to 3 mm. CONCLUSIONS: Interactions between sequential stimulation of pairs of electrodes in a suprachoroidal retinal prosthesis occur for delays up to 100 ms and electrode separations of several millimeters. Knowledge of these spatiotemporal interactions is essential for developing effective patterns of stimulation for retinal prostheses.en_US
dc.description.sponsorshipThis work was supported by the Australian Research Council through its Special Research Initiative in Bionic Vision Science and Technology awarded to Bionic Vision Australia and by the Bertalli Family Foundation to the Bionics Institute. The Bionics Institute acknowledges the support received from the Victorian Government through its Operational Infrastructure Program.en_US
dc.identifier.citationCicione, R., Fallon, J. B., Rathbone, G. D., Williams, C. E., & Shivdasani, M. N. (2014). Spatiotemporal interactions in the visual cortex following paired electrical stimulation of the retina. Investigative Ophthalmology & Visual Science, 55(12), 7726-7738.en_US
dc.identifier.issn1552-5783 (Electronic) 0146-0404 (Linking)
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/121
dc.language.isoenen_US
dc.publisherThe Association for Research in Vision and Ophthalmology Inc.en_US
dc.subjectElectric Stimulation/methodsen_US
dc.subjectElectrodesen_US
dc.subjectImplanteden_US
dc.subjectEvoked Potentialsen_US
dc.subjectVisual/physiologyen_US
dc.subjectModels, Animalen_US
dc.subjectRetina/ physiology/surgeryen_US
dc.subjectSensory Thresholds/physiologyen_US
dc.subjectVisual Cortex/ physiologyen_US
dc.subjectVisual Perception/ physiologyen_US
dc.subjectVisual Prosthesisen_US
dc.titleSpatiotemporal interactions in the visual cortex following paired electrical stimulation of the retinaen_US
dc.typeArticleen_US
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