Determining the Contribution of Retinotopic Discrimination to Localization Performance With a Suprachoroidal Retinal Prosthesis

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dc.contributor.authorPetoe, Matthew
dc.contributor.authorMcCarthy, Chris
dc.contributor.authorShivdasani, Mohit
dc.contributor.authorSinclair, Nicholas
dc.contributor.authorScott, Adele
dc.contributor.authorAyton, Lauren
dc.contributor.authorBarnes, Nick
dc.contributor.authorBionic Vision Australia Consortium
dc.date.accessioned2017-07-04T00:46:34Z
dc.date.available2017-07-04T00:46:34Z
dc.date.issued2017-06
dc.description.abstractPurpose: With a retinal prosthesis connected to a head-mounted camera, subjects can perform low vision tasks using a combination of electrode discrimination and head-directed localization. The objective of the present study was to investigate the contribution of retinotopic electrode discrimination (perception corresponding to the arrangement of the implanted electrodes with respect to their position beneath the retina) to visual performance for three recipients of a 24-channel suprachoroidal retinal implant. Proficiency in retinotopic discrimination may allow good performance with smaller head movements, and identification of this ability would be useful for targeted rehabilitation. Methods: Three participants with retinitis pigmentosa performed localization and grating acuity assessments using a suprachoroidal retinal prosthesis. We compared retinotopic and nonretinotopic electrode mapping and hypothesized that participants with measurable acuity in a normal retinotopic condition would be negatively impacted by the nonretinotopic condition. We also expected that participants without measurable acuity would preferentially use head movement over retinotopic information. Results: Only one participant was able to complete the grating acuity task. In the localization task, this participant exhibited significantly greater head movements and significantly lower localization scores when using the nonretinotopic electrode mapping. There was no significant difference in localization performance or head movement for the remaining two subjects when comparing retinotopic to nonretinotopic electrode mapping. Conclusions: Successful discrimination of retinotopic information is possible with a suprachoroidal retinal prosthesis. Head movement behavior during a localization task can be modified using a nonretinotopic mapping. Behavioral comparisons using retinotopic and nonretinotopic electrode mapping may be able to highlight deficiencies in retinotopic discrimination, with a view to address these deficiencies in a rehabilitation environment. (ClinicalTrials.gov number, NCT01603576).en_US
dc.description.sponsorshipSupported by the Australian Research Council through its Special Research Initiative in Bionic Vision Science and Technology awarded to Bionic Vision Australia, an NHMRC Project Grant 1082358 awarded to PJ Allen, and by the Bertalli Family and Clive & Vera Ramaciotti Foundations to the Bionics Institute; the Victorian Government through its Operational Infrastructure Program (Bionics Institute and the Centre for Eye Research Australia [CERA]); and a National Health and Medical Research Council, Centre for Clinical Research Excellence Award #529923 (CERA).en_US
dc.identifier.citationPetoe, M. A., C. D. McCarthy, M. N. Shivdasani, N. C. Sinclair, A. F. Scott, L. N. Ayton, N. M. Barnes, R. H. Guymer, P. J. Allen, P. J. Blamey, and Consortium Bionic Vision Australia. 2017. Determining the Contribution of Retinotopic Discrimination to Localization Performance With a Suprachoroidal Retinal Prosthesis. Investigative Ophthalmology & Visual Science. 58(7): 3231-39.en_US
dc.identifier.issn1552-5783 (Electronic) 0146-0404 (Linking)
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/248
dc.language.isoenen_US
dc.publisherIOVSen_US
dc.subjectRetinal prosthesisen_US
dc.subjectSuprachoroidalen_US
dc.subjectLocalizationen_US
dc.subjectDiscriminationen_US
dc.subjectRetinitis pigmentosaen_US
dc.titleDetermining the Contribution of Retinotopic Discrimination to Localization Performance With a Suprachoroidal Retinal Prosthesisen_US
dc.typeArticleen_US
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