Engineering Biocoatings To Prolong Drug Release from Supraparticles

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dc.contributor.authorMa, Yutian
dc.contributor.authorCortez-Jugo, Christina
dc.contributor.authorLi, Jianhua
dc.contributor.authorLin, Zhixing
dc.contributor.authorRichardson, Rachael
dc.contributor.authorHan, Yiyuan
dc.contributor.authorZhou, Jiajing
dc.contributor.authorBjörnmalm, Mattias
dc.contributor.authorFeeney, Orlagh
dc.contributor.authorZhong, Qi-Zhi
dc.contributor.authorPorter, Christopher
dc.contributor.authorWise, Andrew
dc.contributor.authorCaruso, Frank
dc.date.accessioned2019-08-27T04:01:41Z
dc.date.available2019-08-27T04:01:41Z
dc.date.issued2019-08
dc.description.abstractSupraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of interest for long-term, sustained drug release in biomedical applications. However, a key challenge to achieving temporal control of drug release from SPs is the occurrence of an initial rapid release of the loaded drug (i.e., "burst" release) that limits sustained release and potentially causes burst release-associated drug toxicity. Herein, a biocoating strategy is presented for silica-SPs (Si-SPs) to reduce the extent of burst release of the loaded model protein lysozyme. Specifically, Si-SPs were coated with a fibrin film, formed by enzymatic conversion of fibrinogen into fibrin. The fibrin-coated Si-SPs, (F)Si-SPs, which could be loaded with 7.9 +/- 0.9 mug of lysozyme per SP, released >60% of cargo protein over a considerably longer period of time of >20 days when compared with the uncoated Si-SPs that released the same amount of the cargo protein, however, within the first 3 days. Neurotrophins that support the survival and differentiation of neurons could also be loaded at approximately 7.3 mug per SP, with fibrin coating also delaying neurotrophin release (only 10% of cargo released over 21 days compared with 60% from Si-SPs). In addition, the effects of incorporating a hydrogel-based system for surgical delivery and the opportunity to control drug release kinetics were investigated-an alginate-based hydrogel scaffold was used to encapsulate (F)Si-SPs. The introduction of the hydrogel further extended the initial release of the encapsulated lysozyme to approximately 40 days (for the same amount of cargo released). The results demonstrate the increasing versatility of the SP drug delivery platform, combining large loading capacity with sustained drug release, that is tailorable using different modes of controlled delivery approaches.en_US
dc.description.sponsorshipThis research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036), the Australian National Health and Medical Research Council (NHMRC) Project grants GNT1064375 and GNT1142910, the US Department of Defense (W81XWH1810276), and the Robert Bulley Foundation. F.C. acknowledges the award of an NHMRC Senior Principal Research Fellowship (GNT1135806). The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. M.B. acknowledges support from Horizon 2020 (European Union) through a Marie Skłodowska-Curie Individual Fellowship (grant agreement no. 745676). We also thank Dr. Yi Ju and Yijiao Qu for helpful discussions.en_US
dc.identifier.citationMa, Y., C. Cortez-Jugo, J. Li, Z. Lin, R. T. Richardson, Y. Han, J. Zhou, M. Bjornmalm, O. M. Feeney, Q. Z. Zhong, C. J. H. Porter, A. K. Wise, and F. Caruso. 2019. Engineering Biocoatings To Prolong Drug Release from Supraparticles. Biomacromolecules: [epub ahead of print].en_US
dc.identifier.issn1525-7797
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/361
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.titleEngineering Biocoatings To Prolong Drug Release from Supraparticlesen_US
dc.typeArticleen_US
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