Head and Gaze Behavior in Retinitis Pigmentosa

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dc.contributor.authorTitchener, Samuel
dc.contributor.authorAyton, Lauren
dc.contributor.authorAbbott, Carla
dc.contributor.authorFallon, James
dc.contributor.authorShivdasani, Mohit
dc.contributor.authorCaruso, Emily
dc.contributor.authorSivarajah, Pyrawy
dc.contributor.authorPetoe, Matthew
dc.date.accessioned2019-06-03T05:09:40Z
dc.date.available2019-06-03T05:09:40Z
dc.date.issued2019-05
dc.description.abstractPurpose: Peripheral visual field loss (PVFL) due to retinitis pigmentosa (RP) decreases saccades to areas of visual defect, leading to a habitually confined range of eye movement. We investigated the relative contributions of head and eye movement in RP patients and normal-sighted controls to determine whether this reduced eye movement is offset by increased head movement. Methods: Eye-head coordination was examined in 18 early-moderate RP patients, 4 late-stage RP patients, and 19 normal-sighted controls. Three metrics were extracted: the extent of eye, head, and total gaze (eye+head) movement while viewing a naturalistic scene; head gain, the ratio of head movement to total gaze movement during smooth pursuit; and the customary oculomotor range (COMR), the orbital range within which the eye is preferentially maintained during a pro-saccade task. Results: The late-stage RP group had minimal gaze movement and could not discern the naturalistic scene. Variance in head position in early-moderate RP was significantly greater than in controls, whereas variance in total gaze was similar. Head gain was greater in early-moderate RP than in controls, whereas COMR was smaller. Across groups, visual field extent was negatively correlated with head gain and positively correlated with COMR. Accounting for age effects, these results demonstrate increased head movement at the expense of eye movement in participants with PVFL. Conclusions: RP is associated with an increased propensity for head movement during gaze shifts, and the magnitude of this effect is dependent on the severity of visual field loss.en_US
dc.description.sponsorshipSupported by the Clive and Vera Ramaciotti Foundation (MAP; Health Investment Grant) and by the Bertalli Family Foundation to the Bionics Institute, project grants from the National Health and Medical Research Council (GNT 1063093 awarded to MNS, GNT 1082358 awarded to LNA and MAP), and the Melbourne Neuroscience Institute Australian Government Research Training Program (SAT). The Bionics Institute and the Centre for Eye Research Australia receive funding from the Victorian Government through its Operational Infrastructure Program.en_US
dc.identifier.citationTitchener, S. A., L. N. Ayton, C. J. Abbott, J. B. Fallon, M. N. Shivdasani, E. Caruso, P. Sivarajah, and M. A. Petoe. 2019. Head and Gaze Behavior in Retinitis Pigmentosa. Investigative Ophthalmology & Visual Science. 60(6): 2263-2273.en_US
dc.identifier.issn0146-0404
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/354
dc.language.isoenen_US
dc.publisherARVOen_US
dc.subjectRetinitits pigmentosaen_US
dc.subjectEye movementen_US
dc.subjectHead movementen_US
dc.subjectEye-head coordinationen_US
dc.titleHead and Gaze Behavior in Retinitis Pigmentosaen_US
dc.typeArticleen_US
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