Tremor Reduction by Deep Brain Stimulation Is Associated With Gamma Power Suppression in Parkinson's Disease

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dc.contributor.authorBeudel, Martjin
dc.contributor.authorLittle, Simon
dc.contributor.authorPogosyan, Alek
dc.contributor.authorAshkan, Keyoumars
dc.contributor.authorFoltynie, Thomas
dc.contributor.authorLimousin, Patricia
dc.contributor.authorZrinzo, Ludvic
dc.contributor.authorHariz, Marwan
dc.contributor.authorBogdanovic, Marko
dc.contributor.authorCheeran, Binith
dc.contributor.authorGreen, Alexander
dc.contributor.authorAziz, Tipu
dc.contributor.authorThevathasan, Wesley
dc.contributor.authorBrown, Peter
dc.date.accessioned2015-12-24T00:50:32Z
dc.date.available2015-12-24T00:50:32Z
dc.date.issued2015-07
dc.description.abstractObjectives Rest tremor is a cardinal symptom of Parkinson's disease (PD), and is readily suppressed by deep brain stimulation (DBS) of the subthalamic nucleus (STN). The therapeutic effect of the latter on bradykinesia and rigidity has been associated with the suppression of exaggerated beta (13–30 Hz) band synchronization in the vicinity of the stimulating electrode, but there is no correlation between beta suppression and tremor amplitude. In the present study, we investigate whether tremor suppression is related to suppression of activities at other frequencies. Materials and Methods We recorded hand tremor and contralateral local field potential (LFP) activity from DBS electrodes during stimulation of the STN in 15 hemispheres in 11 patients with PD. DBS was applied with increasing voltages starting at 0.5 V until tremor suppression was achieved or until 4.5 V was reached. Results Tremor was reduced to 48.9% ± 10.9% of that without DBS once stimulation reached 2.5–3 V (t14 = −4.667, p < 0.001). There was a parallel suppression of low gamma (31–45 Hz) power to 92.5% ± 3% (t14 = −2.348, p = 0.034). This was not seen over a band containing tremor frequencies and their harmonic (4–12 Hz), or over the beta band. Moreover, low gamma power correlated with tremor severity (mean r = 0.43 ± 0.14, p = 0.008) within subjects. This was not the case for LFP power in the other two bands. Conclusions Our findings support a relationship between low gamma oscillations and PD tremor, and reinforce the principle that the subthalamic LFP is a rich signal that may contain information about the severity of multiple different Parkinsonian features.en_US
dc.description.sponsorshipThis work was funded by the Medical Research Council, Rosetrees Trust and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre. The UCL Unit of Functional Neurosurgery is supported by The Parkinson Appeal UK, and the Monument trust. WT is supported by the National Health and Medical Research Council (Australia) and The Brain Foundation (Australia). Theen_US
dc.identifier.citationBeudel, M., S. Little, A. Pogosyan, K. Ashkan, T. Foltynie, P. Limousin, L. Zrinzo, M. Hariz, M. Bogdanovic, B. Cheeran, A. L. Green, T. Aziz, W. Thevathasan & P. Brown (2015). Tremor Reduction by Deep Brain Stimulation Is Associated With Gamma Power Suppression in Parkinson's Disease. Neuromodulation 18(5): 349-354.en_US
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/170
dc.language.isoenen_US
dc.publisherJohn Wiley and Sonsen_US
dc.subjectDeep brain stimulationen_US
dc.subjectmechanisms of actionen_US
dc.subjectParkinson's diseaseen_US
dc.subjectsubthalamic nucleusen_US
dc.subjecttremoren_US
dc.titleTremor Reduction by Deep Brain Stimulation Is Associated With Gamma Power Suppression in Parkinson's Diseaseen_US
dc.typeArticleen_US
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