Vitamin D-deficient diet rescues hearing loss in Klotho mice
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Date
2010-12-08
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Klotho-deficient mice exhibit a premature aging syndrome, a feature of which is mild hearing loss. In the
present study, the hearing phenotype of Klotho mice was characterized to better determine how well
this phenotype resembles presbycusis in humans. It was demonstrated that Klotho animals have
auditory-evoked brainstem response (ABR) threshold shifts of 14e18 dB in response to pure tone stimuli
of 4, 8, 16 and 32 kHz, and similarly, in response to clicks; however, cochlear histology and spiral ganglion
neuron density appeared normal in these mice. It was further demonstrated that a vitamin D-deficient
diet normalizes serum calcitriol (1,25(OH)2D3) levels and prevents hearing loss in Klotho mice. It is
concluded that hearing loss in Klotho mice is caused by elevated renal 1a-hydroxylase expression and
consequent excessive production of calcitriol. These findings implicate the vitamin D metabolic pathway
in hearing loss and pose questions as to the mechanism by which elevated calcitriol levels mediate such
hearing loss.
Description
http://www.journals.elsevier.com/hearing-research/
Keywords
Hearing, Hearing Loss, Mouse, Presbycusis, Klotho, Vitamin D, Deficient
Citation
Carpinelli, M. R., Wise, A. K., & Burt, R. A. (2011). Vitamin D-deficient diet rescues hearing loss in Klotho mice. Hearing Research, 275(1-2), 105-109.