Treating hearing disorders with cell and gene therapy
| dc.contributor.author | Gillespie, Lisa | |
| dc.contributor.author | Richardson, Rachael | |
| dc.contributor.author | Nayagam, Bryony | |
| dc.contributor.author | Wise, Andrew | |
| dc.date.accessioned | 2015-11-09T05:08:52Z | |
| dc.date.available | 2015-11-09T05:08:52Z | |
| dc.date.issued | 2014-10 | |
| dc.description.abstract | Hearing loss is an increasing problem for a substantial number of people and, with an aging population, the incidence and severity of hearing loss will become more significant over time. There are very few therapies currently available to treat hearing loss, and so the development of new therapeutic strategies for hearing impaired individuals is of paramount importance to address this unmet clinical need. Most forms of hearing loss are progressive in nature and therefore an opportunity exists to develop novel therapeutic approaches to slow or halt hearing loss progression, or even repair or replace lost hearing function. Numerous emerging technologies have potential as therapeutic options. This paper details the potential of cell- and gene-based therapies to provide therapeutic agents to protect sensory and neural cells from various insults known to cause hearing loss; explores the potential of replacing lost sensory and nerve cells using gene and stem cell therapy; and describes the considerations for clinical translation and the challenges that need to be overcome. | en_US |
| dc.description.sponsorship | Grant support was received from the following organisations: The National Health and Medical Research Council of Australia GNT1024350, GNT1023372 and GNT1064375; The Garnett Passe and Rodney Williams Memorial Foundation; The University of Melbourne, Departments of Audiology and Speech Pathology and Otolaryngology; The Royal Victorian Eye and Ear Hospital; and Action on Hearing Loss. The Bionics Institute also acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. | en_US |
| dc.identifier.citation | Gillespie, L. N., R. T. Richardson, B. A. Nayagam and A. K. Wise (2014). Treating hearing disorders with cell and gene therapy. J Neural Eng 11(6): 065001. | en_US |
| dc.identifier.issn | 1741-2552 (Electronic) 1741-2552 (Linking) | |
| dc.identifier.uri | http://repository.bionicsinstitute.org:8080/handle/123456789/141 | |
| dc.language.iso | en | en_US |
| dc.publisher | IOP Publishing | en_US |
| dc.subject | hearing loss | en_US |
| dc.subject | gene therapy | en_US |
| dc.subject | cell therapy | en_US |
| dc.subject | stem cell therapy | en_US |
| dc.subject | cochlear implant | en_US |
| dc.title | Treating hearing disorders with cell and gene therapy | en_US |
| dc.type | Article | en_US |