Spectral distribution of local field potential responses to electrical stimulation of the retina
| dc.contributor.author | Wong, Yan | |
| dc.contributor.author | Halupka, Kerry | |
| dc.contributor.author | Kameneva, Tatiana | |
| dc.contributor.author | Cloherty, Shaun | |
| dc.contributor.author | Grayden, David | |
| dc.contributor.author | Burkitt, Anthony | |
| dc.contributor.author | Meffin, Hamish | |
| dc.contributor.author | Shivdasani, Mohit | |
| dc.date.accessioned | 2017-09-06T02:01:23Z | |
| dc.date.available | 2017-09-06T02:01:23Z | |
| dc.date.issued | 2016-03 | |
| dc.description.abstract | OBJECTIVE: Different frequency bands of the local field potential (LFP) have been shown to reflect neuronal activity occurring at varying cortical scales. As such, recordings of the LFP may offer a novel way to test the efficacy of neural prostheses and allow improvement of stimulation strategies via neural feedback. Here we use LFP measurements from visual cortex to characterize neural responses to electrical stimulation of the retina. We aim to show that the LFP is a viable signal that contains sufficient information to optimize the performance of sensory neural prostheses. APPROACH: Clinically relevant electrode arrays were implanted in the suprachoroidal space of one eye in four felines. LFPs were simultaneously recorded in response to stimulation of individual electrodes using penetrating microelectrode arrays from the visual cortex. The frequency response of each electrode was extracted using multi-taper spectral analysis and the uniqueness of the responses was determined via a linear decoder. MAIN RESULTS: We found that cortical LFPs are reliably modulated by electrical stimulation of the retina and that the responses are spatially localized. We further characterized the spectral distribution of responses, with maximum information being contained in the low and high gamma bands. Finally, we found that LFP responses are unique to a large range of stimulus parameters ( approximately 40) with a maximum conveyable information rate of 6.1 bits. SIGNIFICANCE: These results show that the LFP can be used to validate responses to electrical stimulation of the retina and we provide the first steps towards using these responses to provide more efficacious stimulation strategies. | en_US |
| dc.description.sponsorship | This research was supported by the Australian Research Council's Discovery Projects funding scheme (DP140104533) and through its Special Research Initiative (SRI) in Bionic Vision Science and Technology awarded to Bionic Vision Australia (BVA) SR1000005. The contribution of MNS was funded by a project grant from the National Health and Medical Research Council Australia (GNT1063093). The research was also supported by the Bertalli Family Foundation through the Bionics Institute. The Bionics Institute acknowledges the support received from the Victorian Government through its Operational Infrastructure Program. This research was supported by a Victorian Life Sciences Computation Initiative (VLSCI) grant number [VR0138] on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, Australia. | en_US |
| dc.identifier.citation | Wong, Y. T., K. Halupka, T. Kameneva, S. L. Cloherty, D. B. Grayden, A. N. Burkitt, H. Meffin, and M. N. Shivdasani. 2016. Spectral distribution of local field potential responses to electrical stimulation of the retina. Journal of Neural Engineering. 13(3): 036003. | en_US |
| dc.identifier.issn | 1741-2552 (Electronic) 1741-2552 (Linking) | |
| dc.identifier.uri | http://repository.bionicsinstitute.org:8080/handle/123456789/260 | |
| dc.language.iso | en | en_US |
| dc.publisher | IOP Publishing | en_US |
| dc.subject | Local field potentials | en_US |
| dc.subject | Vision prosthesis | en_US |
| dc.subject | Retinal prosthesis | en_US |
| dc.subject | Decoding | en_US |
| dc.title | Spectral distribution of local field potential responses to electrical stimulation of the retina | en_US |
| dc.type | Article | en_US |