Functional neuroplasticity in response to cerebello-thalamic injury underpins the clinical presentation of tremor in multiple sclerosis

Simple item page
dc.contributor.authorBoonstra, Frederique
dc.contributor.authorNoffs, Gustavo
dc.contributor.authorPerera, Thushara
dc.contributor.authorJokubaitis, Vilija
dc.contributor.authorVogel, Adam
dc.contributor.authorMoffat, Bradford
dc.contributor.authorButzkueven, Helmut
dc.contributor.authorEvans, Andrew
dc.contributor.authorvan der Walt, Anneke
dc.contributor.authorKolbe, Scott
dc.date.accessioned2020-03-02T03:57:51Z
dc.date.available2020-03-02T03:57:51Z
dc.date.issued2019-03
dc.description.abstractBACKGROUND:: Tremor is present in almost half of multiple sclerosis (MS) patients. The lack of understanding of its pathophysiology is hampering progress in development of treatments. OBJECTIVES:: To clarify the structural and functional brain changes associated with the clinical phenotype of upper limb tremor in people with MS. METHODS:: Fifteen healthy controls (46.1 +/- 15.4 years), 27 MS participants without tremor (46.7 +/- 11.6 years) and 42 with tremor (46.6 +/- 11.5 years) were included. Tremor was quantified using the Bain score (0-10) for overall severity, handwriting and Archimedes spiral drawing. Functional magnetic resonance imaging activations were compared between participants groups during performance of a joystick task designed to isolate tremulous movement. Inflammation and atrophy of cerebello-thalamo-cortical brain structures were quantified. RESULTS:: Tremor participants were found to have atrophy of the cerebellum and thalamus, and higher ipsilateral cerebellar lesion load compared to participants without tremor ( p < 0.020). We found higher ipsilateral activation in the inferior parietal lobule, the premotor cortex and supplementary motor area in MS tremor participants compared to MS participants without tremor during the joystick task. Finally, stronger activation in those areas was associated with lower tremor severity. CONCLUSION:: Subcortical neurodegeneration and inflammation along the cerebello-thalamo-cortical and cortical functional neuroplasticity contribute to the severity of tremor in MS.en_US
dc.description.sponsorshipThis project was funded by an NHMRC Project Grant (1085461 CIA Van der Walt). The Bionics Institute receives Operational Infrastructure Support from the Victorian Government.en_US
dc.identifier.citationBoonstra, F. M., G. Noffs, T. Perera, V. G. Jokubaitis, A. P. Vogel, B. A. Moffat, H. Butzkueven, A. Evans, A. van der Walt, and S. C. Kolbe. 2019. Functional neuroplasticity in response to cerebello-thalamic injury underpins the clinical presentation of tremor in multiple sclerosis. Multiple Sclerosis Journal: [epub ahead of print].en_US
dc.identifier.issn1352-4585
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/388
dc.language.isoenen_US
dc.publisherSAGE Publishingen_US
dc.subjectMultiple sclerosisen_US
dc.subjectFunctional magnetic resonance imagingen_US
dc.subjectMagnetic resonance imagingen_US
dc.titleFunctional neuroplasticity in response to cerebello-thalamic injury underpins the clinical presentation of tremor in multiple sclerosisen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2019_Boonstra_Functional.pdf
Size:
56.61 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
BI publications