No Consistent Antidepressant Effects of Deep Brain Stimulation of the Bed Nucleus of the Stria Terminalis.

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dc.contributor.authorFitzgerald, Paul B
dc.contributor.authorHoy, Kate
dc.contributor.authorRichardson, Karyn E
dc.contributor.authorGainsford, Kirsten
dc.contributor.authorSegrave, Rebecca
dc.contributor.authorHerring, Sally E
dc.contributor.authorDaskalakis, Zafiris J
dc.contributor.authorBittar, Richard G
dc.date.accessioned2024-07-30T00:45:10Z
dc.date.available2024-07-30T00:45:10Z
dc.date.issued2024-05-14T14:00:00Z
dc.description.abstractApplying deep brain stimulation (DBS) to several brain regions has been investigated in attempts to treat highly treatment-resistant depression, with variable results. Our initial pilot data suggested that the bed nucleus of the stria terminalis (BNST) could be a promising therapeutic target.
dc.description.abstractThe aim of this study was to gather blinded data exploring the efficacy of applying DBS to the BNST in patients with highly refractory depression.
dc.description.abstractEight patients with chronic severe treatment-resistant depression underwent DBS to the BNST. A randomised, double-blind crossover study design with fixed stimulation parameters was followed and followed by a period of open-label stimulation.
dc.description.abstractDuring the double-blind crossover phase, no consistent antidepressant effects were seen with any of the four stimulation parameters applied, and no patients achieved response or remission criteria during the blinded crossover phase or during a subsequent period of three months of blinded stimulation. Stimulation-related side effects, especially agitation, were reported by a number of patients and were reversible with adjustment of the stimulation parameters.
dc.description.abstractThe results of this study do not support the application of DBS to the BNST in patients with highly resistant depression or ongoing research utilising stimulation at this brain site. The blocked randomised study design utilising fixed stimulation parameters was poorly tolerated by the participants and does not appear suitable for assessing the efficacy of DBS at this location.
dc.description.sponsorshipWe would like to thank the patients who participated in this study and who contributed immeasurably.
dc.identifier.citationFitzgerald, P.B.; Hoy, K.; Richardson, K.E.; Gainsford, K.; Segrave, R.; Herring, S.E.; Daskalakis, Z.J.; Bittar, R.G. No Consistent Antidepressant Effects of Deep Brain Stimulation of the Bed Nucleus of the Stria Terminalis. Brain Sci. 2024, 14, 499. https://doi.org/10.3390/brainsci14050499
dc.identifier.urihttps://repository.bionicsinstitute.org/handle/123456789/455
dc.language.isoen
dc.publisherBrain Sciences
dc.subjectbed nucleus of the stria terminalis
dc.subjectclinical response
dc.subjectdeep brain stimulation
dc.subjectmajor depression
dc.subjecttreatment resistance
dc.titleNo Consistent Antidepressant Effects of Deep Brain Stimulation of the Bed Nucleus of the Stria Terminalis.
dc.typeArticle
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