Hydrogel limits stem cell dispersal in the deaf cochlea: implications for cochlear implants

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dc.contributor.authorNayagam, Bryony
dc.contributor.authorBackhouse, Steven
dc.contributor.authorCimenkaya, Cengiz
dc.contributor.authorShepherd, Robert
dc.date.accessioned2013-12-02T04:09:02Z
dc.date.available2013-12-02T04:09:02Z
dc.date.issued2012-11-27
dc.description.abstractAuditory neurons provide the critical link between a cochlear implant and the brain in deaf individuals, therefore their preservation and/or regeneration is important for optimal performance of this neural prosthesis. In cases where auditory neurons are significantly depleted, stem cells (SCs) may be used to replace the lost population of neurons, thereby re-establishing the critical link between the periphery (implant) and the brain. For such a therapy to be therapeutically viable, SCs must be differentiated into neurons, retained at their delivery site and damage caused to the residual auditory neurons minimized. Here we describe the transplantation of SC-derived neurons into the deaf cochlea, using a peptide hydrogel to limit their dispersal. The described approach illustrates that SCs can be delivered to and are retained within the basal turn of the cochlea, without a significant loss of endogenous auditory neurons. In addition, the tissue response elicited from this surgical approach was restricted to the surgical site and did not extend beyond the cochlear basal turn. Overall, this approach illustrates the feasibility of targeted cell delivery into the mammalian cochlea using hydrogel, which may be useful for future cell-based transplantation strategies, for combined treatment with a cochlear implant to restore function.en_US
dc.description.sponsorshipDepartment of Otolaryngology, the University of Melbourne, the Garnett Passe and Rodney Williams Memorial Foundation, the Bionics Institute, the Thomas Wickham Jones Foundation (UK), the Royal Victorian Eye and Ear Hospital. The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. B.A. Nayagam is supported by an NH&MRC Australian-Based Biomedical Research Fellowship.en_US
dc.identifier.citationNayagam, B. A., Backhouse, S. S., Cimenkaya, C., & Shepherd, R. K. (2012). Hydrogel limits stem cell dispersal in the deaf cochlea: implications for cochlear implants. Journal of Neural Engineering, 9(6), Article#065001.en_US
dc.identifier.issn1741-2552 (Online)
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/63
dc.language.isoen_USen_US
dc.publisherInstitute of Physicsen_US
dc.subjectCochlear Implanten_US
dc.subjectHydrogelen_US
dc.subjectStem Cellen_US
dc.subjectAuditory Neuronen_US
dc.subjectDeafnessen_US
dc.titleHydrogel limits stem cell dispersal in the deaf cochlea: implications for cochlear implantsen_US
dc.typeArticleen_US
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