Enhanced auditory neuron survival following cell- based BDNF treatment in the deaf guinea pig

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dc.contributor.authorPettingill, Lisa
dc.contributor.authorWise, Andrew
dc.contributor.authorGeaney, Marilyn
dc.contributor.authorShepherd, Robert
dc.date.accessioned2013-05-08T03:29:53Z
dc.date.available2013-05-08T03:29:53Z
dc.date.issued2011-04-05
dc.description.abstractExogenous neurotrophin delivery to the deaf cochlea can prevent deafness-induced auditory neuron degeneration, however, we have previously reported that these survival effects are rapidly lost if the treatment stops. In addition, there are concerns that current experimental techniques are not safe enough to be used clinically. Therefore, for such treatments to be clinically transferable, methods of neurotrophin treatment that are safe, biocompatible and can support long-term auditory neuron survival are necessary. Cell transplantation and gene transfer, combined with encapsulation technologies, have the potential to address these issues. This study investigated the survival-promoting effects of encapsulated BDNF over-expressing Schwann cells on auditory neurons in the deaf guinea pig. In comparison to control (empty) capsules, there was significantly greater auditory neuron survival following the cell-based BDNF treatment. Concurrent use of a cochlear implant is expected to result in even greater auditory neuron survival, and provide a clinically relevant method to support auditory neuron survival that may lead to improved speech perception and language outcomes for cochlear implant patients.en_US
dc.description.sponsorshipFunding for this research was provided by: The Macquarie Bank Foundation, The Garnett Passe and Rodney Williams Memorial Foundation, The National Health and Medical Research Council of Australia, The State Government of Victoria Operational Infrastructure Program, The National Institutes of Health (HHS-N-263-2007-00053-C) and Living Cell Technologies, Limited (LCT). MSG is employed by LCT and played a role in the cell encapsulation aspects of the experiments.en_US
dc.identifier.citationPettingill, L. N., Wise, A. K., Geaney, M. S., & Shepherd, R. K. (2011). Enhanced auditory neuron survival following cell-based BDNF treatment in the deaf guinea pig. PLoS ONE, 6(4), e18733.en_US
dc.identifier.issn1932-6203
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/25
dc.language.isoenen_US
dc.publisherPLOSen_US
dc.subjectAlginates/pharmacologyen_US
dc.subjectBrain-Derived Neurotrophic Factor/pharmacologyen_US
dc.subjectBrain-Derived Neurotrophic Factor/therapeutic useen_US
dc.subjectCell Survival - drug effectsen_US
dc.subjectCapsulesen_US
dc.subjectCochlear Implantationen_US
dc.subjectCochlear Nerve - drug effectsen_US
dc.subjectCochlear Nerve - pathologyen_US
dc.subjectDeafness - drug therapyen_US
dc.subjectDeafness - pathologyen_US
dc.subjectGlucuronic Acid - pharmacologyen_US
dc.subjectGuinea Pigsen_US
dc.subjectHexuronic Acids - pharmacologyen_US
dc.subjectNeurons - drug effectsen_US
dc.subjectNeurons - pathologyen_US
dc.subjectRatsen_US
dc.subjectSchwann Cells - drug effectsen_US
dc.subjectSchwann Cells - transplantationen_US
dc.subjectTransfectionen_US
dc.titleEnhanced auditory neuron survival following cell- based BDNF treatment in the deaf guinea pigen_US
dc.typeArticleen_US
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