Neural Responses to Multielectrode Stimulation of Healthy and Degenerate Retina

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dc.contributor.authorHalupka, Kerry
dc.contributor.authorAbbott, Carla
dc.contributor.authorWong, Yan
dc.contributor.authorCloherty, Shaun
dc.contributor.authorGrayden, David
dc.contributor.authorBurkitt, Anthony
dc.contributor.authorSergeev, Evgeni
dc.contributor.authorBrandli, Alice
dc.contributor.authorAllen, Penelope
dc.contributor.authorMeffin, Hamish
dc.contributor.authorShivdasani, Mohit
dc.date.accessioned2017-07-31T04:35:30Z
dc.date.available2017-07-31T04:35:30Z
dc.date.issued2017-07
dc.description.abstractPurpose: Simultaneous stimulation of multiple retinal electrodes in normally sighted animals shows promise in improving the resolution of retinal prostheses. However, the effects of simultaneous stimulation on degenerate retinae remain unknown. Therefore, we investigated the characteristics of cortical responses to multielectrode stimulation of the degenerate retina. Methods: Four adult cats were bilaterally implanted with retinal electrode arrays in the suprachoroidal space after unilateral adenosine triphosphate (ATP)-induced retinal photoreceptor degeneration. Functional and structural changes were characterized by using electroretinogram a-wave amplitude and optical coherence tomography. Multiunit activity was recorded from both hemispheres of the visual cortex. Responses to single- and multielectrode stimulation of the ATP-injected and fellow control eyes were characterized and compared. Results: The retinae of ATP-injected eyes displayed structural and functional changes consistent with mid- to late-stage photoreceptor degeneration and remodeling. Responses to multielectrode stimulation of the ATP-injected eyes exhibited shortened latencies, lower saturated spike counts, and higher thresholds, compared to stimulation of the fellow control eyes. Electrical receptive field sizes were significantly larger in the ATP-injected eye than in the control eye, and positively correlated with the extent of degeneration. Conclusions: Significant differences exist between cortical responses to stimulation of healthy and degenerate retinae. Our results highlight the importance of using a retinal degeneration model when evaluating the efficacy of novel stimulation paradigms.en_US
dc.description.sponsorshipSupported by a Project Grant from the National Health and Medical Research Council, Australia (GNT No. 1063093). This research was additionally supported by the Australian Research Council through its Special Research Initiative in Bionic Vision Science and Technology awarded to Bionic Vision Australia and the Bertalli Family Foundation to the Bionics Institute. The Bionics Institute and the Centre for Eye Research Australia acknowledge the support they receive from the Victorian Government through its Operational Infrastructure Program. KJH was supported by an Australian Postgraduate Award through the Australian Government and a postgraduate scholarship from the Commonwealth Scientific and Industrial Research Organisation (CSIRO). ANB and YTW acknowledge support under the Australian Research Council’s Discovery Projects funding scheme (Project DP140104533).en_US
dc.identifier.citationHalupka, K. J., C. J. Abbott, Y. T. Wong, S. L. Cloherty, D. B. Grayden, A. N. Burkitt, E. N. Sergeev, C. D. Luu, A. Brandli, P. J. Allen, H. Meffin, and M. N. Shivdasani. 2017. Neural Responses to Multielectrode Stimulation of Healthy and Degenerate Retina. Investigative Ophthalmology & Visual Science. 58(9): 3770-84.en_US
dc.identifier.issn0146-0404
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/250
dc.language.isoenen_US
dc.publisherIOVSen_US
dc.subjectRetinal prosthesisen_US
dc.subjectRetinal degenerationen_US
dc.subjectIn vivo electrophysiologyen_US
dc.subjectElectrical stimulationen_US
dc.subjectComputational modelinen_US
dc.titleNeural Responses to Multielectrode Stimulation of Healthy and Degenerate Retinaen_US
dc.typeArticleen_US
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