Neurophysiological correlates of non-motor symptoms in late premanifest and early-stage manifest huntington's disease.

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dc.contributor.authorDavis, Marie-Claire
dc.contributor.authorHill, Aron T
dc.contributor.authorFitzgerald, Paul B
dc.contributor.authorBailey, Neil W
dc.contributor.authorStout, Julie C
dc.contributor.authorHoy, Kate E
dc.date.accessioned2024-04-12T04:36:06Z
dc.date.available2024-04-12T04:36:06Z
dc.date.issued2023-09
dc.description.abstractTo find sensitive neurophysiological correlates of non-motor symptoms in Huntington's disease (HD), which are essential for the development and assessment of novel treatments.
dc.description.abstractWe used resting state EEG to examine differences in oscillatory activity (analysing the isolated periodic as well as the complete EEG signal) and functional connectivity in 22 late premanifest and early stage people with HD and 20 neurotypical controls. We then assessed the correlations between these neurophysiological markers and clinical measures of apathy and processing speed.
dc.description.abstractSignificantly lower theta and greater delta resting state power was seen in the HD group, as well as significantly greater delta connectivity. There was a significant positive correlation between theta power and processing speed, however there were no associations between the neurophysiological and apathy measures.
dc.description.abstractWe speculate that these changes in oscillatory power and connectivity reflect ongoing, frontally concentrated degenerative and compensatory processes associated with HD.
dc.description.abstractOur findings support the potential utility of quantitative EEG as a proximate marker of processing speed, but not apathy in HD.
dc.description.sponsorshipMCD was supported by the Research Training Program Stipend and a Monash Graduate Excellence Scholarship. KEH was supported by National Health and Medical Research Council (NHMRC) Fellowships (1082894 and 1135558). PBF was supported by an Investigator Fellowship from the NHMRC (1193596). ATH was supported by an Alfred Deakin Postdoctoral Research Fellowship. We gratefully acknowledge the time, involvement, and feedback from the participants. This research would not have been possible without them. We also acknowledge the assistance with participant recruitment provided by the Statewide Progressive Neurological Disease Service at Calvary Health Care Bethlehem.
dc.identifier.citationMarie-Claire Davis, Aron T. Hill, Paul B. Fitzgerald, Neil W. Bailey, Julie C. Stout, Kate E. Hoy, Neurophysiological correlates of non-motor symptoms in late premanifest and early-stage manifest huntington's disease, Clinical Neurophysiology, Volume 153, 2023, Pages 166-176, ISSN 1388-2457, https://doi.org/10.1016/j.clinph.2023.06.021. (https://www.sciencedirect.com/science/article/pii/S1388245723006764)
dc.identifier.urihttps://repository.bionicsinstitute.org/handle/123456789/453
dc.language.isoen
dc.publisherClinical Neurophysiology
dc.subjectApathy
dc.subjectElectroencephalography (EEG)
dc.subjectFunctional connectivity
dc.subjectHuntington’s disease (HD)
dc.subjectProcessing speed
dc.titleNeurophysiological correlates of non-motor symptoms in late premanifest and early-stage manifest huntington's disease.
dc.typeArticle
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