Graphene foam as a biocompatible scaffold for culturing human neurons

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dc.contributor.authorD'Abaco, Giovanna
dc.contributor.authorMattei, Cristiana
dc.contributor.authorNasr, Babak
dc.contributor.authorHudson, Emma
dc.contributor.authorAlshawaf, Abdullah
dc.contributor.authorChana, Gursharan
dc.contributor.authorEverall, Ian
dc.contributor.authorNayagam, Bryony
dc.contributor.authorDottori, Mirella
dc.contributor.authorSkafidas, Efstratios
dc.date.accessioned2018-04-23T06:31:37Z
dc.date.available2018-04-23T06:31:37Z
dc.date.issued2018-04
dc.description.abstractIn this study, we explore the use of electrically active graphene foam as a scaffold for the culture of human-derived neurons. Human embryonic stem cell (hESC)-derived cortical neurons fated as either glutamatergic or GABAergic neuronal phenotypes were cultured on graphene foam. We show that graphene foam is biocompatible for the culture of human neurons, capable of supporting cell viability and differentiation of hESC-derived cortical neurons. Based on the findings, we propose that graphene foam represents a suitable scaffold for engineering neuronal tissue and warrants further investigation as a model for understanding neuronal maturation, function and circuit formation.en_US
dc.description.sponsorshipThis studywas supported by the University of Melbourne and Australian Research Council funding. B.N. was supported by ARC Centre of Excellence for Integrative Brain Function. M.D. was supported by an Australian Research Council Future Fellowship. A.J.A. was supported by the Saudi Arabian Ministry of Higher Education (Saudi Arabia). E.S. is supported by the Clifford Chair in Neural Engineering.en_US
dc.identifier.citationD'Abaco, G. M., C. Mattei, B. Nasr, E. J. Hudson, A. J. Alshawaf, G. Chana, I. P. Everall, B. Nayagam, M. Dottori, and E. Skafidas. 2018. Graphene foam as a biocompatible scaffold for culturing human neurons. Royal Society Open Science. 5(3): 171364.en_US
dc.identifier.issn2054-5703 (Print) 2054-5703
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/294
dc.language.isoenen_US
dc.publisherRoyal Society Open Scienceen_US
dc.subjectGraphene foamen_US
dc.subjectBiocompatibilityen_US
dc.subjectHuman stem cellsen_US
dc.subjectHuman cortical neuronsen_US
dc.titleGraphene foam as a biocompatible scaffold for culturing human neuronsen_US
dc.typeArticleen_US
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