Subthalamic Nucleus Deep Brain Stimulation Evokes Resonant Neural Activity
| dc.contributor.author | Sinclair, Nicholas | |
| dc.contributor.author | McDermott, Hugh | |
| dc.contributor.author | Bulluss, Kristian | |
| dc.contributor.author | Fallon, James | |
| dc.contributor.author | Perera, Thushara | |
| dc.contributor.author | Xu, San San | |
| dc.contributor.author | Brown, Peter | |
| dc.contributor.author | Thevathasan, Wesley | |
| dc.date.accessioned | 2018-05-09T04:11:57Z | |
| dc.date.available | 2018-05-09T04:11:57Z | |
| dc.date.issued | 2018-05 | |
| dc.description.abstract | Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target-specific biomarker is required to optimize therapy. Here, we show that DBS evokes a large-amplitude resonant neural response focally in the subthalamic nucleus. This response is greatest in the dorsal region (the clinically optimal stimulation target for Parkinson disease), coincides with improved clinical performance, is chronically recordable, and is present under general anesthesia. These features make it a readily utilizable electrophysiological signal that could potentially be used for guiding electrode implantation surgery and tailoring DBS therapy to improve patient outcomes. | en_US |
| dc.description.sponsorship | This work was supported by the Colonial Foundation, St Vincent’s Hospital Research Endowment Fund, and the National Health and Medical Research Council (project grant # 1103238). The Bionics Institute acknowledges the support it receives from the Victorian Government through its operational infrastructure program. N.C.S. is supported by an Australian Government Research Training Program Scholarship. S.S.X and W.T. are supported by the National Health and Medical Research Council. W.T. is supported by Lions International. P.B. is supported by the Medical Research Council of Great Britain (MC_UU_12024/1). | en_US |
| dc.identifier.citation | Sinclair, N. C., H. J. McDermott, K. J. Bulluss, J. B. Fallon, T. Perera, S. S. Xu, P. Brown, and W. Thevathasan. 2018. Subthalamic nucleus deep brain stimulation evokes resonant neural activity. Annals of neurology: [epub ahead of print]. | en_US |
| dc.identifier.issn | 0364-5134 | |
| dc.identifier.uri | http://repository.bionicsinstitute.org:8080/handle/123456789/298 | |
| dc.language.iso | en | en_US |
| dc.publisher | Wiley Periodicals, Inc. | en_US |
| dc.subject | Deep brain stimulation | en_US |
| dc.title | Subthalamic Nucleus Deep Brain Stimulation Evokes Resonant Neural Activity | en_US |
| dc.type | Article | en_US |