An in vivo investigation of first spike latencies in the inferior colliculus in response to multichannel penetrating auditory brainstem implant stimulation
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Date
2010-05-04
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IOP Publishing Ltd
Abstract
The cochlear nucleus (CN) is the first auditory processing site within the brain and the target
location of the auditory brainstem implant (ABI), which provides speech perception to patients
who cannot benefit from a cochlear implant (CI). Although there is variance between ABI
recipient speech performance outcomes, performance is typically low compared to CI
recipients. Temporal aspects of neural firing such as first spike latency (FSL) are thought to
code for many speech features; however, no studies have investigated FSL from CN
stimulation. Consequently, ABIs currently do not incorporate CN-specific temporal
information. We therefore systematically investigated inferior colliculus (IC) neuron’s FSL
response to frequency-specific electrical stimulation of the CN in rats. The range of FSLs from
electrical stimulation of many neurons indicates that both monosynaptic and polysynaptic
pathways were activated, suggesting initial activation of multiple CN neuron types. Electrical
FSLs for a single neuron did not change irrespective of the CN frequency region stimulated,
indicating highly segregated projections from the CN to the IC. These results present the first
evidence of temporal responses to frequency-specific CN electrical stimulation.
Understanding the auditory system’s temporal response to electrical stimulation will help in
future ABI designs and stimulation strategies.
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Citation
Mauger, S. J., Shivdasani, M. N., Rathbone, G. D., Argent, R. E., & Paolini, A. G. (2010). An in vivo investigation of first spike latencies in the inferior colliculus in response to multichannel penetrating auditory brainstem implant stimulation. Journal of neural engineering, 7(3), 036004.