Biocompatibility of Immobilized Aligned Carbon Nanotubes

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dc.contributor.authorNayagam, David
dc.contributor.authorWilliams, Richard
dc.contributor.authorChen, Jun
dc.contributor.authorMagee, Kylie
dc.contributor.authorIrwin, Jennifer
dc.contributor.authorTan, Justin
dc.contributor.authorInnis, Peter
dc.contributor.authorLeung, Ronald
dc.contributor.authorFinch, Sue
dc.contributor.authorWilliams, Chris
dc.contributor.authorClark, Graeme
dc.contributor.authorWallace, Gordon
dc.date.accessioned2017-08-23T06:54:38Z
dc.date.available2017-08-23T06:54:38Z
dc.date.issued2011
dc.description.abstractIn vivo host responses to an electrode-like array of aligned carbon nanotubes (ACNTs) embedded within a biopolymer sheet are reported. This biocompatibility study assesses the suitability of immobilized carbon nanotubes for bionic devices. Inflammatory responses and foreign-body histiocytic reactions are not substantially elevated when compared to negative controls following 12 weeks implantation. A fibrous capsule isolates the implanted ACNTs from the surrounding muscle tissue. Filamentous nanotube fragments are engulfed by macrophages, and globular debris is incorporated into the fibrous capsule with no further reaction. Scattered leukocytes are observed, adherent to the ACNT surface. These data indicate that there is a minimal local foreign-body response to immobilized ACNTs, that detached fragments are phagocytosed into an inert material, and that ACNTs do not attract high levels of surface fouling. Collectively, these results suggest that immobilized nanotube structures should be considered for further investigation as bionic components.en_US
dc.description.sponsorshipWe acknowledge the Australian Research Council (ARC) Centre of Excellence for Electromaterials Science (ACES) for providing principle funding and support for this study. We also acknowledge the support of the ARC through its Special Research Initiative (SRI) in Bionic Vision Science and Technology grant to Bionic Vision Australia (BVA). D.A.X.N. received surgical training from the Royal Australasian College of Surgeons through a study scholarship from The Victorian Neurotrauma Initiative (VNI). The Bionic Ear Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. The authors would like to thank: Atha Palios and the staff of St. Vincent’s Hospital Department of Anatomical Pathology; Sue Pierce for veterinary guidance; Sue McKay, Liliana Pepe, Anna Destereos, Amanda Rixon at St. Vincent’s Hospital Experimental Micro Surgery Unit for animal care; Elisa Borg and Christopher Baird at The Royal Victorian Hospital Biological Research Centre for breeding and supplying guinea pigs; Phil Francis and Royal Melbourne Institute of Technology Microscopy & Microanalysis Facility for training and access to electron microscopy, Stewart Gresham for laboratory, administrative and experimental support; Maria Clarke and Prudence Nielsen at the University of Melbourne, Department of Otolaryngology for histological support; Rachael Richardson and Nicole Fretwell for early pilots; and Bryony Nayagam, Dexter Irvine, and Rob Shepherd for constructive comments on the manuscript.en_US
dc.identifier.citationNayagam, David A. X., Richard A. Williams, Jun Chen, Kylie A. Magee, Jennifer Irwin, Justin Tan, Peter Innis, Ronald T. Leung, Sue Finch, Chris E. Williams, Graeme M. Clark, and Gordon G. Wallace. 2011. Biocompatibility of immobilized aligned carbon nanotubes. Small. 7(8): 1035-42.en_US
dc.identifier.issn1613-6829
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/256
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectCarbon nanotubesen_US
dc.subjectChronic diseasesen_US
dc.subjectBiocompabilityen_US
dc.subjectImplantsen_US
dc.titleBiocompatibility of Immobilized Aligned Carbon Nanotubesen_US
dc.typeArticleen_US
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