Are long stimulus pulse durations the answer to improving spatial resolution in retinal prostheses?

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dc.contributor.authorPetoe, Matthew
dc.contributor.authorShivdasani, Mohit
dc.date.accessioned2017-01-31T02:35:55Z
dc.date.available2017-01-31T02:35:55Z
dc.date.issued2016-11
dc.description.abstractRetinal prostheses can provide artificial vision to patients with degenerate retinae by electrically stimulating the remaining inner retinal neurons. The evoked perception is generally adequate for light localization, but of limited spatial resolution owing to the indiscriminate activation of multiple retinal cell types, leading to distortions in the perceived image. Here we present a perspective on a recent work by Weitz and colleagues who demonstrate a focal confinement of retinal ganglion cell (RGC) activation when using extended pulse durations in the stimulation waveform. Using real-time calcium imaging, they provide evidence that long pulse durations selectively stimulate inner retinal neurons, whilst avoiding unwanted axonal activations. The application of this stimulation technique may provide enhanced spatial resolution for retinal prosthesis users. These experiments provide a robust analysis of the effects of increasing pulse duration and introduce the potential for alternative stimulation paradigms in retinal prostheses.en_US
dc.identifier.citation[1] M.A. Petoe, M.N. Shivdasani, Are long stimulus pulse durations the answer to improving spatial resolution in retinal prostheses?, Ann Transl Med, 4 (2016) 434.en_US
dc.identifier.issn2305-5839 (Print) 2305-5839 (Linking)
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/227
dc.publisherAnnals of Translational Medicineen_US
dc.subjectRetinal prosthesesen_US
dc.subjectRetinitis pigmentosa (RP)en_US
dc.subjectCalcium imagingen_US
dc.subjectSpatial resolutionen_US
dc.subjectRetinaen_US
dc.titleAre long stimulus pulse durations the answer to improving spatial resolution in retinal prostheses?en_US
dc.typeArticleen_US
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