Chronic electrical stimulation with a peripheral suprachoroidal retinal implant: a preclinical safety study of neuroprotective stimulation.

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dc.contributor.authorAbbott, Carla J
dc.contributor.authorAllen, Penelope J
dc.contributor.authorWilliams, Chris E
dc.contributor.authorWilliams, Richard A
dc.contributor.authorEpp, Stephanie B
dc.contributor.authorBurns, Owen
dc.contributor.authorThomas, Ross
dc.contributor.authorHarrison, Mark
dc.contributor.authorThien, Patrick C
dc.contributor.authorSaunders, Alexia
dc.contributor.authorMcGowan, Ceara
dc.contributor.authorSloan, Caitlin
dc.contributor.authorLuu, Chi D
dc.contributor.authorNayagam, David A X
dc.date.accessioned2024-08-14T23:55:58Z
dc.date.available2024-08-14T23:55:58Z
dc.date.issued2024-06-20
dc.description.abstractExtraocular electrical stimulation is known to provide neuroprotection for retinal cells in retinal and optic nerve diseases. Currently, the treatment approach requires patients to set up extraocular electrodes and stimulate potentially weekly due to the lack of an implantable stimulation device. Hence, a minimally-invasive implant was developed to provide chronic electrical stimulation to the retina, potentially improving patient compliance for long-term use. The aim of the present study was to determine the surgical and stimulation safety of this novel device designed for neuroprotective stimulation.
dc.description.abstractEight normally sighted adult feline subjects were monocularly implanted in the suprachoroidal space in the peripheral retina for 9-39 weeks. Charge balanced, biphasic, current pulses (100 μA, 500 µs pulse width and 50 pulses/s) were delivered continuously to platinum electrodes for 3-34 weeks. Electrode impedances were measured hourly. Retinal structure and function were assessed at 1-, 2-, 4-, 6- and 8-month using electroretinography, optical coherence tomography and fundus photography. Retina and fibrotic thickness were measured from histological sections. Randomized, blinded histopathological assessments of stimulated and non-stimulated retina were performed.
dc.description.abstractAll subjects tolerated the surgical and stimulation procedure with no evidence of discomfort or unexpected adverse outcomes. The device position was stable after a post-surgery settling period. Median electrode impedance remained within a consistent range (5-10 kΩ) over time. There was no change in retinal thickness or function relative to baseline and fellow eyes. Fibrotic capsule thickness was equivalent between stimulated and non-stimulated tissue and helps to hold the device in place. There was no scarring, insertion trauma, necrosis, retinal damage or fibroblastic response in any retinal samples from implanted eyes, whilst 19% had a minimal histiocytic response, 19% had minimal to mild acute inflammation and 28% had minimal to mild chronic inflammation.
dc.description.abstractChronic suprathreshold electrical stimulation of the retina using a minimally invasive device evoked a mild tissue response and no adverse clinical findings. Peripheral suprachoroidal electrical stimulation with an implanted device could potentially be an alternative approach to transcorneal electrical stimulation for delivering neuroprotective stimulation.
dc.description.sponsorshipThe authors would like to acknowledge Joel Villalobos for contribution to the design of the cable system, Jenny Zhou, Peter Phan and Angel de Silva for assistance with electrode fabrication, Cesar MSalinas-LaRosa for discussion regarding pathology grading, Elizabeth Baglin for assisting with the surgical figure and Ella Trang for assisting with the retinal microscopy images.
dc.identifier.citationAbbott CJ, Allen PJ, Williams CE, Williams RA, Epp SB, Burns O, Thomas R, Harrison M, Thien PC, Saunders A, McGowan C, Sloan C, Luu CD, Nayagam DAX. Chronic electrical stimulation with a peripheral suprachoroidal retinal implant: a preclinical safety study of neuroprotective stimulation. Front Cell Dev Biol. 2024 Jun 20;12:1422764. doi: 10.3389/fcell.2024.1422764. PMID: 38966426; PMCID: PMC11222648.
dc.identifier.urihttps://repository.bionicsinstitute.org/handle/123456789/460
dc.language.isoen
dc.publisherFrontiers
dc.subjectelectrical stimulation
dc.subjectelectroretinography
dc.subjectneuroprotection
dc.subjectretinal histopathology
dc.subjectretinal implant
dc.subjectsurgical feasibility
dc.titleChronic electrical stimulation with a peripheral suprachoroidal retinal implant: a preclinical safety study of neuroprotective stimulation.
dc.typeArticle
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