Probucol-bile acid nanoparticles: a novel approach and promising solution to prevent cellular oxidative stress in sensorineural hearing loss.

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dc.contributor.authorWagle, Susbin Raj
dc.contributor.authorKovacevic, Bozica
dc.contributor.authorFoster, Thomas
dc.contributor.authorIonescu, Corina Mihaela
dc.contributor.authorJones, Melissa
dc.contributor.authorMikov, Momir
dc.contributor.authorWise, Andrew
dc.contributor.authorMooranian, Armin
dc.contributor.authorAl-Salami, Hani
dc.date.accessioned2024-08-15T00:12:41Z
dc.date.available2024-08-15T00:12:41Z
dc.date.issued2024-06-21
dc.description.abstractThe use of antioxidants could thus prove an effective medication to prevent or facilitate recovery from oxidative stress-induced sensorineural hearing loss (SNHL). One promising strategy to prevent SNHL is developing probucol (PB)-based nanoparticles using encapsulation technology and administering them to the inner ear via the established intratympanic route. The preclinical, clinical and epidemiological studies support that PB is a proven antioxidant that could effectively prevent oxidative stress in different study models. Such findings suggest its applicability in preventing oxidative stress within the inner ear and its associated neural cells. However, several hurdles, such as overcoming the blood-labyrinth barrier, ensuring sustained release, minimising systemic side effects and optimising targeted delivery in the intricate inner ear structures, must be overcome to efficiently deliver PB to the inner ear. This review explores the background and pathogenesis of hearing loss, the potential of PB in treating oxidative stress and its cellular mechanisms, and the obstacles linked to inner ear drug delivery for effectively introducing PB to the inner ear.
dc.identifier.citationCite Wagle SR, Kovacevic B, Foster T, Ionescu CM, Jones M, Mikov M, Wise A, Mooranian A, Al-Salami H. Probucol-bile acid nanoparticles: a novel approach and promising solution to prevent cellular oxidative stress in sensorineural hearing loss. J Drug Target. 2024 Aug;32(7):737-755. doi: 10.1080/1061186X.2024.2349111. Epub 2024 Jun 21. PMID: 38758361.
dc.identifier.urihttps://repository.bionicsinstitute.org/handle/123456789/461
dc.language.isoen
dc.publisherJournal of Drug Targeting
dc.subjectSensorineural hearing loss
dc.subjectbile acid
dc.subjectencapsulation
dc.subjectfree radical
dc.subjectnanoparticle
dc.subjectoxidative stress
dc.subjectprobucol
dc.titleProbucol-bile acid nanoparticles: a novel approach and promising solution to prevent cellular oxidative stress in sensorineural hearing loss.
dc.typeArticle
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