Gentamicin Applied to the Oval Window Suppresses Vestibular Function in Guinea Pigs

Simple item page
dc.contributor.authorKing, Elisha
dc.contributor.authorShepherd, Robert
dc.contributor.authorBrown, Daniel
dc.contributor.authorFallon, James
dc.date.accessioned2018-01-09T04:33:11Z
dc.date.available2018-01-09T04:33:11Z
dc.date.issued2017-01
dc.description.abstractIntratympanic gentamicin therapy is widely used clinically to treat the debilitating symptoms of Meniere's disease. Cochleotoxicity is an undesirable potential side effect of the treatment and the risk of hearing loss increases proportionately with gentamicin concentration in the cochlea. It has recently been shown that gentamicin is readily absorbed through the oval window in guinea pigs. The present study uses quantitative functional measures of vestibular and cochlea function to investigate the efficacy of treating the vestibule by applying a small volume of gentamicin onto the stapes footplate in guinea pigs. Vestibular and cochlea function were assessed by recording short latency vestibular evoked potentials in response to linear head acceleration and changes in hearing threshold, respectively, 1 and 2 weeks following treatment. Histopathology was analyzed in the crista ampullaris of the posterior semi-circular canal and utricular macula in the vestibule, and in the basal and second turns of the cochlea. In animals receiving gentamicin on the stapes footplate, vestibular responses were significantly suppressed by 72.7 % 2 weeks after treatment with no significant loss of hearing. This suggests that the vestibule can be treated directly by applying gentamicin onto the stapes footplate.en_US
dc.description.sponsorshipThis study was funded by the Garnett Passe & Rodney Williams Memorial Foundation. The time invested by A/Prof Fallon, Prof Shepherd, Dr. Brown were supported by research grants from the NHMRC (GNT1081478) and the Garnett Passe and Rodney Williams Memorial Foundation.en_US
dc.identifier.citationKing, E. B., R. K. Shepherd, D. J. Brown, and J. B. Fallon. 2017. Gentamicin Applied to the Oval Window Suppresses Vestibular Function in Guinea Pigs. Journal of the Association for Research in Otolaryngology : JARO. 18(2): 291-99.en_US
dc.identifier.issn1438-7573
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/276
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectGentamicinen_US
dc.subjectAminoglycosideen_US
dc.subjectVestibulotoxicityen_US
dc.subjectOtotoxicityen_US
dc.subjectOval windowen_US
dc.subjectStapesen_US
dc.subjectStapediovestibular jointen_US
dc.subjectAnnular ligamenten_US
dc.subjectIntratympanicen_US
dc.subjectPharmacokineticsen_US
dc.titleGentamicin Applied to the Oval Window Suppresses Vestibular Function in Guinea Pigsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2017_King_Gentamicinapplied.pdf
Size:
192.65 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
BI publications