Development and Characterization of a Sucrose Microneedle Neural Electrode Delivery System

Simple item page
dc.contributor.authorApollo, Nicholas
dc.contributor.authorJiang, Jonathon
dc.contributor.authorCheung, Warwick
dc.contributor.authorBaquier, Sebastien
dc.contributor.authorLai, Alan
dc.contributor.authorMirebedini, Azadeh
dc.contributor.authorForoughi, Javad
dc.contributor.authorWallace, Gordon
dc.contributor.authorShivdasani, Mohit
dc.contributor.authorPrawer, Steven
dc.contributor.authorChen, Shou
dc.contributor.authorWilliams, Richard
dc.contributor.authorCook, Mark
dc.contributor.authorNayagam, David
dc.contributor.authorGarrett, David
dc.date.accessioned2018-12-18T00:03:35Z
dc.date.available2018-12-18T00:03:35Z
dc.date.issued2017-12
dc.description.abstractStable brain–machine interfaces present extraordinary therapeutic and scientific promise. However, the electrode–tissue interface is susceptible to instability and damage during long-term implantation. Soft, flexible electrodes demonstrate improved longevity, but pose a new challenge with regard to simple and accurate surgical implantation. A high aspect ratio water-soluble microneedle is developed based on sucrose which permits straightforward surgical implantation of soft, flexible microelectrodes. Here, a description of the microneedle manufacturing process is presented, along with in vitro and in vivo safety and efficacy assessments. Successful fabrication requires control of the glass transition temperature of aqueous sucrose solutions. The insertion force of 5 different microneedle electrode vehicles is studied in agarose brain phantoms, with the sucrose microneedle eliciting the lowest insertion force and strain energy transfer. Short- and long-term assessments of the pathological response to sucrose microneedle implantations in the brain suggest minimal tissue reactions, comparable to those observed following stainless-steel hypodermic needle punctures. Finally, microelectrodes fabricated from graphene, carbon nanotubes, or platinum are embedded in sucrose microneedles and implanted into an epileptic rat model for 22 d. All electrodes are functional throughout the implantation period, with the graphene electrode exhibiting the largest seizure signal-to-noise ratio and only modest changes in impedance.en_US
dc.description.sponsorshipThis work was supported by the MMICSIRO materials science scholarship for N.V.A. N.V.A. and D.J.G. were supported by an NHMRC Project Grant. J.F. was supported by a DECRA fellowship (DE12010517). The Bionics Institute acknowledges the Victoria State Government for Operational Infrastructure Funding. The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript.en_US
dc.identifier.citationApollo, N. V., J. Jiang, W. Cheung, S. Baquier, A. Lai, A. Mirebedini, J. Foroughi, G. G. Wallace, M. N. Shivdasani, S. Prawer, S. Chen, R. Williams, M. J. Cook, D. A. X. Nayagam, and D. J. Garrett. 2017. Development and Characterization of a Sucrose Microneedle Neural Electrode Delivery System. Advanced Biosystems: 1700187.en_US
dc.identifier.issn2366-7478
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/328
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectBrain-machine interfacesen_US
dc.subjectCarbon nanotubesen_US
dc.subjectElectrophysiologyen_US
dc.subjectGrapheneen_US
dc.subjectWater soluble microneedlesen_US
dc.titleDevelopment and Characterization of a Sucrose Microneedle Neural Electrode Delivery Systemen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2017_Apollo_Development.pdf
Size:
2.21 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
BI publications