Clinical validation of a precision electromagnetic tremor measurement system in participants receiving deep brain stimulation for essential tremor

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dc.contributor.authorPerera, Thushara
dc.contributor.authorYohanandan, Shivanthan
dc.contributor.authorThevathasan, Wesley
dc.contributor.authorJones, Mary
dc.contributor.authorPeppard, Richard
dc.contributor.authorEvans, Andrew
dc.contributor.authorTan, Joy
dc.contributor.authorMcKay, Colette
dc.contributor.authorMcDermott, Hugh
dc.date.accessioned2017-09-11T05:55:35Z
dc.date.available2017-09-11T05:55:35Z
dc.date.issued2016-08
dc.description.abstractTremor is characterized commonly through subjective clinical rating scales. Accelerometer-based techniques for objective tremor measurement have been developed in the past, yet these measures are usually presented as an unintuitive dimensionless index without measurement units. Here we have developed a tool (TREMBAL) to provide quantifiable and objective measures of tremor severity using electromagnetic motion tracking. We aimed to compare TREMBAL's objective measures with clinical tremor ratings and determine the test-retest reliability of our technique. Eight participants with ET receiving deep brain stimulation (DBS) therapy were consented. Tremor was simultaneously recorded using TREMBAL and video during DBS adjustment. After each adjustment, participants performed a hands-outstretched task (for postural tremor) and a finger-nose task (for kinetic tremor). Video recordings were de-identified, randomized, and shown to a panel of movement disorder specialists to obtain their ratings. Regression analysis and Pearson's correlations were used to determine agreement between datasets. Subsets of the trial were repeated to assess test-retest reliability. Tremor amplitude and velocity measures were in close agreement with mean clinical ratings (r > 0.90) for both postural and kinetic tremors. Test-retest reliability for both translational and rotational components of tremor showed intra-class correlations >0.80. TREMBAL assessments showed that tremor gradually improved with increasing DBS therapy-this was also supported by clinical observation. TREMBAL measurements are a sensitive, objective and reliable assessment of tremor severity. This tool may have application in clinical trials and in aiding automated optimization of deep brain stimulation.en_US
dc.identifier.citationPerera, T., S. A. Yohanandan, W. Thevathasan, M. Jones, R. Peppard, A. H. Evans, J. L. Tan, C. M. McKay, and H. J. McDermott. 2016. Clinical validation of a precision electromagnetic tremor measurement system in participants receiving deep brain stimulation for essential tremor. Physiological Measurement. 37(9): 1516-27.en_US
dc.identifier.issn1361-6579 (Electronic) 0967-3334 (Linking)
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/264
dc.language.isoenen_US
dc.publisherIOP Publishingen_US
dc.subjectEssential tremoren_US
dc.subjectMotion trackingen_US
dc.subjectDeep brain stimulationen_US
dc.subjectParkinson's diseaseen_US
dc.titleClinical validation of a precision electromagnetic tremor measurement system in participants receiving deep brain stimulation for essential tremoren_US
dc.typeArticleen_US
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