Effects of transcranial direct current stimulation and transcranial random noise stimulation on working memory and task-related EEG in major depressive disorder.
| dc.contributor.author | Murphy, O W | |
| dc.contributor.author | Hoy, K E | |
| dc.contributor.author | Wong, D | |
| dc.contributor.author | Bailey, N W | |
| dc.contributor.author | Fitzgerald, P B | |
| dc.contributor.author | Segrave, R A | |
| dc.date.accessioned | 2024-04-12T04:04:24Z | |
| dc.date.available | 2024-04-12T04:04:24Z | |
| dc.date.issued | 2023-12 | |
| dc.description.abstract | To compare effects of transcranial direct current stimulation (tDCS) and transcranial random noise stimulation with a direct-current offset (tRNS + DC-offset) on working memory (WM) performance and task-related electroencephalography (EEG) in individuals with Major Depressive Disorder (MDD). | |
| dc.description.abstract | Using a sham-controlled, parallel-groups design, 49 participants with MDD received either anodal tDCS (N = 16), high-frequency tRNS + DC-offset (N = 16), or sham stimulation (N = 17) to the left dorsolateral prefrontal cortex (DLPFC) for 20-minutes. The Sternberg WM task was completed with concurrent EEG recording before and at 5- and 25-minutes post-stimulation. Event-related synchronisation/desynchronisation (ERS/ERD) was calculated for theta, upper alpha, and gamma oscillations during WM encoding and maintenance. | |
| dc.description.abstract | tDCS significantly increased parieto-occipital upper alpha ERS/ERD during WM maintenance, observed on EEG recorded 5- and 25-minutes post-stimulation. tRNS + DC-offset did not significantly alter WM-related oscillatory activity when compared to sham stimulation. Neither tDCS nor tRNS + DC-offset improved WM performance to a significantly greater degree than sham stimulation. | |
| dc.description.abstract | Although tDCS induced persistent effects on WM-related oscillatory activity, neither tDCS nor tRNS + DC-offset enhanced WM performance in MDD. | |
| dc.description.abstract | This reflects the first sham-controlled comparison of tDCS and tRNS + DC-offset in MDD. These findings directly contrast with evidence of tRNS-induced enhancements in WM in healthy individuals. | |
| dc.description.sponsorship | This work was supported by a National Health and Medical Research Council (NHMRC) fellowship held by RAS (1036201). OWM was supported by an Australian Government Research Training Program (RTP) Scholarship. PBF is supported by an NHMRC Practitioner Fellowship (1078567). KEH was supported by an NHMRC Fellowship (1135558). We are grateful to A/Prof Greg Siegle for generously providing access to the adaptive PASAT. | |
| dc.identifier.citation | O.W. Murphy, K.E. Hoy, D. Wong, N.W. Bailey, P.B. Fitzgerald, R.A. Segrave, Effects of transcranial direct current stimulation and transcranial random noise stimulation on working memory and task-related EEG in major depressive disorder, Brain and Cognition, Volume 173, 2023, 106105, ISSN 0278-2626, https://doi.org/10.1016/j.bandc.2023.106105. (https://www.sciencedirect.com/science/article/pii/S0278262623001641) | |
| dc.identifier.uri | https://repository.bionicsinstitute.org/handle/123456789/451 | |
| dc.language.iso | en | |
| dc.publisher | Brain and Cognition | |
| dc.subject | Depression | |
| dc.subject | EEG | |
| dc.subject | Transcranial direct current stimulation (tDCS) | |
| dc.subject | Transcranial random noise stimulation (tRNS) | |
| dc.subject | Working memory | |
| dc.title | Effects of transcranial direct current stimulation and transcranial random noise stimulation on working memory and task-related EEG in major depressive disorder. | |
| dc.type | Article |