Drug delivery to the inner ear
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Date
2012-12
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IOP Science
Abstract
Bionic devices electrically activate neural populations to partially restore lost function. Of
fundamental importance is the functional integrity of the targeted neurons. However, in many
conditions the ongoing pathology can lead to continued neural degeneration and death that
may compromise the effectiveness of the device and limit future strategies to improve
performance. The use of drugs that can prevent nerve cell degeneration and promote their
regeneration may improve clinical outcomes. In this paper we focus on strategies of delivering
neuroprotective drugs to the auditory system in a way that is safe and clinically relevant for use
in combination with a cochlear implant. The aim of this approach is to prevent neural
degeneration and promote nerve regrowth in order to improve outcomes for cochlear implant
recipients using techniques that can be translated to the clinic.
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Citation
Wise, A. K & Gillespie, L. N. (2012). Drug delivery to the inner ear. Journal of Neural Engineering 9, article 065002.