Second spatial derivative analysis of cortical surface potentials recorded in cat primary auditory cortex using thin film surface arrays: Comparisons with multi-unit data

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dc.contributor.authorFallon, James
dc.contributor.authorIrving, Sam
dc.contributor.authorPannu, Satinderpall
dc.contributor.authorTooker, Angela
dc.contributor.authorWise, Andrew
dc.contributor.authorShepherd, Robert
dc.contributor.authorIrvine, Dexter
dc.date.accessioned2017-07-03T23:59:05Z
dc.date.available2017-07-03T23:59:05Z
dc.date.issued2016-04
dc.description.abstractBACKGROUND: Current source density analysis of recordings from penetrating electrode arrays has traditionally been used to examine the layer- specific cortical activation and plastic changes associated with changed afferent input. We report on a related analysis, the second spatial derivative (SSD) of surface local field potentials (LFPs) recorded using custom designed thin-film polyimide substrate arrays. RESULTS: SSD analysis of tone- evoked LFPs generated from the auditory cortex under the recording array demonstrated a stereotypical single local minimum, often flanked by maxima on both the caudal and rostral sides. In contrast, tone-pips at frequencies not represented in the region under the array, but known (on the basis of normal tonotopic organization) to be represented caudal to the recording array, had a more complex pattern of many sources and sinks. COMPARISON WITH EXISTING METHODS: Compared to traditional analysis of LFPs, SSD analysis produced a tonotopic map that was more similar to that obtained with multi-unit recordings in a normal-hearing animal. Additionally, the statistically significant decrease in the number of acoustically responsive cortical locations in partially deafened cats following 6 months of cochlear implant use compared to unstimulated cases observed with multi-unit data (p=0.04) was also observed with SSD analysis (p=0.02), but was not apparent using traditional analysis of LFPs (p=0.6). CONCLUSIONS: SSD analysis of surface LFPs from the thin-film array provides a rapid and robust method for examining the spatial distribution of cortical activity with improved spatial resolution compared to more traditional LFP recordings.en_US
dc.description.sponsorshipThis work was funded by the NH&MRC (GNT1002430) andNational Institute of Deafness and Other Communication Disorders(NIH Y1-DC-8002-01) and Lawrence Livermore National Labora-tory. The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program.en_US
dc.identifier.citationFallon, J. B., S. Irving, S. S. Pannu, A. C. Tooker, A. K. Wise, R. K. Shepherd, and D. R. Irvine. 2016. Second spatial derivative analysis of cortical surface potentials recorded in cat primary auditory cortex using thin film surface arrays: Comparisons with multi-unit data. Journal of Neuroscience Methods. 267: 14-20.en_US
dc.identifier.issn1872-678X (Electronic) 0165-0270 (Linking)
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/247
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.subjectLocal field potentialsen_US
dc.subjectCochlear implanten_US
dc.subjectCortical plasticityen_US
dc.subjectNeural prosthesisen_US
dc.subjectSensorineural hearing lossen_US
dc.titleSecond spatial derivative analysis of cortical surface potentials recorded in cat primary auditory cortex using thin film surface arrays: Comparisons with multi-unit dataen_US
dc.typeArticleen_US
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