Suprachoroidal electrical stimulation: Effects of stimulus pulse parameters on visual cortical responses
| dc.contributor.author | John, Sam | |
| dc.contributor.author | Shivdasani, Mohit | |
| dc.contributor.author | Williams, Chris | |
| dc.contributor.author | Morley, John | |
| dc.contributor.author | Shepherd, Robert | |
| dc.contributor.author | Rathbone, Graeme | |
| dc.contributor.author | Fallon, James | |
| dc.date.accessioned | 2013-11-15T02:49:49Z | |
| dc.date.available | 2013-11-15T02:49:49Z | |
| dc.date.issued | 2013-10 | |
| dc.description.abstract | Objective. Neural responses to biphasic constant current pulses depend on stimulus pulse parameters such as polarity, duration, amplitude and interphase gap. The objective of this study was to systematically evaluate and optimize stimulus pulse parameters for a suprachoroidal retinal prosthesis. Approach. Normally sighted cats were acutely implanted with platinum electrode arrays in the suprachoroidal space. Monopolar stimulation comprised of monophasic and biphasic constant current pulses with varying polarity, pulse duration and interphase gap. Multiunit responses to electrical stimulation were recorded in the visual cortex. Main results. Anodal stimulation elicited cortical responses with shorter latencies and required lower charge per phase than cathodal stimulation. Clinically relevant retinal stimulation required relatively larger charge per phase compared with other neural prostheses. Increasing the interphase gap of biphasic pulses reduced the threshold of activation; however, the benefits of using an interphase gap need to be considered in light of the pulse duration and polarity used and other stimulation constraints. Based on our results, anodal first biphasic pulses between 300–1200 µs are recommended for suprachoroidal retinal stimulation. Significance. These results provide insights into the efficacy of different pulse parameters for suprachoroidal retinal stimulation and have implications for the design of safe and clinically relevant stimulators for retinal prostheses. | en_US |
| dc.description.sponsorship | Australian Research Council through its Special Research Initiative in Bionic Vision Science and Technology, Bionic Vision Australia, Bertalli Family Foundation, SJ was supported by a Latrobe University Tuition Full Fee Research Scholarship, the Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program | en_US |
| dc.identifier.citation | John, S., Shivdasani, M. N., Williams, C. E., Morley, J. W., Shepherd, R., Rathbone, G. D., & Fallon, J. B. (2013). Suprachoroidal electrical stimulation: Effects of stimulus pulse parameters on visual cortical responses. Journal of Neural Engineering, 10(5). | en_US |
| dc.identifier.uri | http://repository.bionicsinstitute.org:8080/handle/123456789/58 | |
| dc.language.iso | en | en_US |
| dc.publisher | IOPscience | en_US |
| dc.subject | Bionic Eye | en_US |
| dc.subject | Suprachoroidal | en_US |
| dc.subject | Cortical | en_US |
| dc.subject | Response | en_US |
| dc.title | Suprachoroidal electrical stimulation: Effects of stimulus pulse parameters on visual cortical responses | en_US |
| dc.type | Article | en_US |