Interobserver Agreement of Electrode to Retina Distance Measurements in a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis

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dc.contributor.authorAbbott, Carla
dc.contributor.authorBaglin, Elizabeth
dc.contributor.authorKolic, Maria
dc.contributor.authorMcGuinness, Myra
dc.contributor.authorTitchener, Samuel
dc.contributor.authorYoung, Kiera
dc.contributor.authorYeoh, Jonathan
dc.contributor.authorLuu, Chi
dc.contributor.authorAyton, Lauren
dc.contributor.authorPetoe, Matthew
dc.contributor.authorAllen, Penelope
dc.date.accessioned2022-09-12T00:44:24Z
dc.date.available2022-09-12T00:44:24Z
dc.date.issued2022-09
dc.description.abstractPurpose: The electrode to retina (ER) distance is an important contributory factor to the safety and efficacy of a suprachoroidal retinal prosthesis. Measuring ER distance may be performed by different observers during multisite studies. The aim of this study was to assess the interobserver agreement in measuring ER distance. Methods: Three independent, trained observers measured ER distance from the center of each suprachoroidal electrode to the inner retinal pigment epithelium in spectral-domain optical coherence tomography (SD-OCT) B-scans. A total of 121 ER distance measurements from 77 B-scans collected over 5 months from one subject implanted with a second-generation 44-channel suprachoroidal retinal prosthesis (NCT03406416) were made by each observer. Results: ER distance ranged from 208 to 509 µm. Pearson's correlation coefficient (ρ) showed agreement of 0.99 (95% confidence interval [CI] = 0.98–0.99) in measuring ER for each pairwise comparison. The mean difference in ER distance between observers ranged from 2.4 to 6.4 µm with pairwise limits of agreement (95% CI) of ±20 µm (5.5% of mean). Intraclass correlation coefficient (ICC) showed agreement of 0.98 (95% CI = 0.97–0.99) between observers. Conclusions: There is high agreement in measuring ER distances for suprachoroidal retinal prostheses using our systematic approach between multiple, trained observers, supporting the use of a single observer for each image. Translational Relevance: High interobserver agreement outcomes indicate that multiple, trained observers can be used to take ER measurements across different images in suprachoroidal retinal prosthesis studies. This improves multisite study efficiency and gives confidence in interpreting results relating to the safety and efficacy of suprachoroidal retinal prostheses.en_US
dc.description.sponsorshipSupported by an National Health and Medical Research Council (NHMRC) grant #1082358 to P.J.A., M.A.P., and L.N.A.; NHMRC Investigator Grant #1195713 to L.N.A. Funding support from Bionic Vision Technologies. The Bionics Institute and the Centre for Eye Research Australia wish to acknowledge the support of the Victorian Government through its Operational Infrastructure Support Program. Disclosure: C.J. Abbott, Bionic Vision Technologies (F, R); E.K. Baglin, Bionic Vision Technologies (F, R); M. Kolic, Bionic Vision Technologies (F, R); M.B. McGuinness, None; S.A. Titchener, Bionic Vision Technologies (F); K.A. Young, None; J. Yeoh, None; C.D. Luu, None; L.N. Ayton, None; M.A. Petoe, Bionics Institute and Centre for Eye Research Australia (P), Bionic Vision Technologies (R); P.J. Allen, Bionics Institute and Centre for Eye Research Australia (P), Bionic Vision Technologies (F)en_US
dc.identifier.citationAbbott CJ, Baglin EK, Kolic M, McGuinness MB, Titchener SA, Young KA, Yeoh J, Luu CD, Ayton LN, Petoe MA, Allen PJ. Interobserver Agreement of Electrode to Retina Distance Measurements in a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis. Trans Vis Sci Tech. 2022;11(9):4. doi:10.1167/tvst.11.9.4en_US
dc.identifier.issn2164-2591
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/422
dc.language.isoenen_US
dc.publisherTranslational Vision Science & Technologyen_US
dc.subjectElectrodesen_US
dc.subjectObserver Variationen_US
dc.subjectHumansen_US
dc.subjectRetina/diagnostic imagingen_US
dc.subjectRetina/Surgeryen_US
dc.subjectTomography, Optical Coherence/methodsen_US
dc.subjectVisual Prosthesisen_US
dc.titleInterobserver Agreement of Electrode to Retina Distance Measurements in a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesisen_US
dc.typeArticleen_US
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