What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis

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dc.contributor.authorNoffs, Gustavo
dc.contributor.authorPerera, Thushara
dc.contributor.authorKolbe, Scott
dc.contributor.authorShanahan, Camille
dc.contributor.authorBoonstra, Frederique
dc.contributor.authorEvans, Andrew
dc.contributor.authorButzkueven, Helmut
dc.contributor.authorvan der Walt, Anneke
dc.contributor.authorVogel, Adam
dc.date.accessioned2019-12-09T00:44:53Z
dc.date.available2019-12-09T00:44:53Z
dc.date.issued2018-12
dc.description.abstractIMPORTANCE: Multiple sclerosis produces neurological impairments that are variable in duration, severity and quality. Speech is frequently impaired, resulting in decreased communication skills and quality of life. Advancements in technology now makes it possible to use quantitative acoustic assessment of speech as biomarkers of disease progression. OBSERVATIONS: Four domains of speech have been identified: articulation (slow articulation and imprecise consonants), voice (pitch and loudness instability), respiration (decreased phonatory time and expiratory pressure) and prosody (longer and frequent pauses, deficient loudness control). Studies also explored I) predictive models for diagnosis of MS and of ataxia using speech variables, II) the relationship of dysarthria with cognition and III) very few studies correlated neuroimaging with dysarthria. We could not identify longitudinal studies of speech or dysarthria in Multiple Sclerosis. CONCLUSION AND RELEVANCE: Refinement of objective measures of speech has enhanced our understanding of Multiple Sclerosis-related deficits in cross-sectional analysis while both integrative and longitudinal studies are identified as major gaps. This review highlights the potential for using quantitative acoustic assessments as clinical endpoints for diagnosing, monitoring progression and treatment in disease modifying trials.en_US
dc.identifier.citationNoffs, G., T. Perera, S. C. Kolbe, C. J. Shanahan, F. M. C. Boonstra, A. Evans, H. Butzkueven, A. van der Walt, and A. P. Vogel. 2018. What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis. Autoimmunity reviews. 17(12): 1202-1209.en_US
dc.identifier.issn1568-9972
dc.identifier.urihttp://repository.bionicsinstitute.org:8080/handle/123456789/371
dc.language.isoenen_US
dc.publisherElsevier, Inc.en_US
dc.subjectMultiple sclerosisen_US
dc.subjectDysarthriaen_US
dc.subjectSpeechen_US
dc.subjectDysphoniaen_US
dc.subjectVoiceen_US
dc.subjectCognitionen_US
dc.subjectQuality of Lifeen_US
dc.subjectDeep Brain Stimulationen_US
dc.subjectAcousticsen_US
dc.titleWhat speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosisen_US
dc.typeArticleen_US
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