Browsing by Author "Yip, Xiaopei"
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- ItemNanoporous peptide particles for encapsulating and releasing neurotrophic factors in an animal model of neurodegeneration.(Wiley Online, 2012-07) Tan, Justin; Wang, Yajun; Yip, Xiaopei; Glynn, Fergal; Shepherd, Robert; Caruso, FrankNeurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons in the cochlea of guinea pigs with sensorineural hearing loss.